Development and pharmacokinetic evaluation of erythromycin lipidic formulations for oral administration in rainbow trout (Oncorhynchus mykiss)
Serdoz, Francesca (Author), Voinovich, Dario (Author), Perissutti, Beatrice (Author), Grabnar, Iztok (Author), Hasa, Dritan (Author), Ballestrazzi, Rodolfo (Author), Coni, Ettore (Author), Pellegrini, Enrico (Author)

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The aim of this work was to enhance the bioavailability of erythromycin base when administered orally in rainbow trout (Oncorhynchus mykiss). Since erythromicin is normally given in the form of medicated feed, in this study 3 new types of feed formulation were developed. A self-emulsifying system and two types of double microemulsions (O/W/O) were prepared, characterised and adsorbed on a commercial extruded diet for fish. The emulsified systems were based on saturated polyglycolized glycerides and mono- and diglycerides of medium chain fatty acids (as oily phase), Tweenr 80 (as surfactant) and, in the case of double microemulsions, distilled water. The systems differed in percentage composition and for the amount and position of erythromycin in different phases. The three medicated feed were then administered orally by means of a gastric probe to rainbow trout and their relative bioavailability was estimated in comparison to that obtained after oral administration of feed with erythromycin powder. For each medicated feed, 80 fish were tested. Finally, plasma profiles of erythromycin after single administration of medicated feeds were used to predict profiles obtainable by administering once daily medicated feeds for 7 consecutive days. The results proved that the feeds containing microemulsified erythromycin provided largely superior oral bioavailability and the advantage of obtaining the same efficacy against bacterial infections with a much lower dose of drug.

Keywords:eritromicin, farmakokinetika, mikroemulzije, akvakultura
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Number of pages:str. 401-407
Numbering:Vol. 78, no. 3
ISSN on article:0939-6411
DOI:10.1016/j.ejpb.2011.03.007 Link is opened in a new window
COBISS.SI-ID:2975089 Link is opened in a new window
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Title:European journal of pharmaceutics and biopharmaceutics
Shortened title:Eur. j. pharm. biopharm.
Publisher:Wiss. Verl.-Ges.
COBISS.SI-ID:13176839 New window

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