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Current view on nanosized solid lipid carriers for drug delivery to the skin
Kristl, Julijana (Avtor), Teskač, Karmen (Avtor), Ahlin Grabnar, Pegi (Avtor)

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Izvleček
Drug delivery into the skin is problematic because, as a natural barrier, it has a very low permeation rate. Several approaches have been made to increase the latter. Current advances in materials science and nanotechnology promise the development of new generations of drug carriers for therapeutic, diagnostic and protective purposes. We have reviewed various lipid drug delivery systems to the skin, with the main focus on solid lipid nanoparticles(SLNs). Further the article concerns possible variants in formulation of SLNs, the selection of lipid compounds and safe stabilizers, and the influence of the physicochemical properties of the drugs on distribution after loading into SLNs. In the last part the advantages of delivery into keratinocytes by SLNs over that of the free drug is addressed, focusing on decreased cytotoxicity of the incorporated drug in SLNs and controlled drug delivery to the subcellular compartments. This knowledge is important in the design and production of advanced solid lipid drug carriers. Additionally, the need for novel approaches or devices to improving permeationis also discussed in the context of moving the nanocarriers to targets deeper in the skin.

Jezik:Angleški jezik
Ključne besede:trdni lipidni nosilci, nanodelci, koža, transport učinkovin
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 529-542
Številčenje:Vol. 6, no. 5
UDK:66.02
ISSN pri članku:1550-7033
COBISS.SI-ID:2927217 Povezava se odpre v novem oknu
Število ogledov:783
Število prenosov:173
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Journal of biomedical nanotechnology
Skrajšan naslov:J. biomed. nanotechnol.
Založnik:American Scientific Publishers
ISSN:1550-7033
COBISS.SI-ID:2927473 Povezava se odpre v novem oknu

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