izpis_h1_title_alt

Increased plasma levels of CATS mRNA but not CATB mRNA in patients with coronary atherosclerosis
Štern, Irma (Avtor), Marc, Janja (Avtor), Kranjec, Igor (Avtor), Zorman, Darko (Avtor), Černe, Andreja (Avtor), Černe, Darko (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TDD-513VKGS-5&_user=4776866&_coverDate=12%2F31%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=8d0b397d06e59096360e99a5ddd6761a&searchtype=a Povezava se odpre v novem oknu

Izvleček
Background: We hypothesized that patients with coronary atherosclerosis have increased plasma levels of cathepsin S (CATS) and cathepsin B (CATB) mRNA, the genes that are involved in atherosclerotic plaque development and destabilization. Methods: mRNAs were isolated from plasma of 67 patients with coronary atherosclerosis (29 with stable angina, 38 with acute coronary syndrome) and 33 healthy subjects as controls, transcribed to cDNA and quantified by real-time PCR. Results: Plasma levels were successfully measured in all samples. Patients with coronary atherosclerosis had 2.75 times higher plasma levels of CATS mRNA than controls (median 6.10 vs. 2.22; pb0.001). No difference was observed in CATB mRNA levels (median 5.62 vs. 6.19; p=0.866). Patients on therapy with statins and aspirin tended to have higher plasma levels of CATS mRNA than patients without statins and aspirin (median 6.41 vs. 4.27; p=0.028). Conclusions: Further evaluation of plasma CATS mRNA levels in patients with coronary atherosclerosis is reasonable.

Jezik:Angleški jezik
Ključne besede:mRNA, plazma, koronarna ateroskleroza, CATS, CATB
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 1427-1430
Številčenje:vol. 43, iss. 18
UDK:577
ISSN pri članku:0009-9120
COBISS.SI-ID:2926193 Povezava se odpre v novem oknu
Število ogledov:450
Število prenosov:151
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Clinical biochemistry
Skrajšan naslov:Clin. biochem.
Založnik:Elsevier.
ISSN:0009-9120
COBISS.SI-ID:22275033 Povezava se odpre v novem oknu

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj