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Oral bioavailability of silymarin phytocomplex formulated as self-emulsifying pellets
Iosio, T. (Author), Voinovich, Dario (Author), Perissutti, Beatrice (Author), Serdoz, Francesca (Author), Hasa, Dritan (Author), Grabnar, Iztok (Author), Dall'Acqua, Stefano (Author), Zara, G.P. (Author), Muntoni, E. (Author), Pinto, J.F. (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science/journal/09447113 This link opens in a new window

Abstract
The objective of this study was to develop new solid self-emulsifying pellets to deliver milk thistle extract (silymarin). These pellets were prepared via extrusion/spheronisation procedure, using a self-emulsifying system or SES (Akoline MCMr, Miglyolr, Tween 80r, soy lecithin and propylene glycol), microcrystalline cellulose and lactose monohydrate. To select the most suitable formulations for extrusion and spheronisation, an experimental design of experiences was adopted. The screening amongst formulations (13 different blends) was performed preparing pellets and evaluating extrusion profiles and quality of the spheronised extrudates. The pellets were characterised for size and shape, density, force required to crush them. Although more than one type of pellets demonstrated adequate morphological and technological characteristics, pellets prepared from formulation 7 revealed the best properties and were selected for further biopharmaceutical investigations, including in vitro dissolution and in vivo trials on rats to study serum and lymph levels after oral administration of the pellets. These preliminary technological and pharmacokinetic data demonstrated that extrusion/spheronisation is a viable technology to produce self-emulsifying pellets of good quality and able to improve in vivo oral bioavailability of main components of a phytotherapeutic extract of more than 100 times by enhancing the lymphatic route of absorption.

Language:English
Keywords:Silybum marianum, pelete, nosilni sistemi, oralna biološka razpoložljivost
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2011
Number of pages:str. 505-512
Numbering:Vol. 18, iss. 6
UDC:543
ISSN on article:0944-7113
DOI:10.1016/j.phymed.2010.10.012 Link is opened in a new window
COBISS.SI-ID:2912113 Link is opened in a new window
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Downloads:176
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Record is a part of a journal

Title:Phytomedicine
Shortened title:Phytomedicine
Publisher:Fischer
ISSN:0944-7113
COBISS.SI-ID:17566981 This link opens in a new window

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