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A new approach for increasing ascorbyl palmitate stability by addition of non-irritant co-antioxidant
Gosenca Matjaž, Mirjam (Avtor), Obreza, Aleš (Avtor), Pečar, Slavko (Avtor), Gašperlin, Mirjana (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.springerlink.com/content/7849287v251r2497/fulltext.pdf Novo okno

Izvleček
The aim of this work was to test innovative approach for enhancing ascorbyl palmitate stability in microemulsions for topical application by addition of newly synthesized co-antioxidant 4-(tridecyloxy)benzaldehyde oxime(TDBO) and to investigate its antioxidant activity and finally to evaluate cytotoxicity of TDBO-loaded microemulsions on keratinocyte cells. TDBO significantly increased ascorbyl palmitate stability in oil-dispersed-in-water (o/w) microemulsions, most presumably due to reduction of ascorbyl palmitate radical back to ascorbyl palmitate, since TDBO free-radical scavenging activity was confirmed. Cytotoxicity experiments demonstrated no significant change in cell viability or morphology in the presence of TDBO-loaded microemulsions regarding unloaded microemulsions, although greater cytotoxicity was observed with increased microemulsion concentrations. Therefore, the incorporation of TDBO as non-cytotoxic co-antioxidant in o/w microemulsions is a promising new strategy for enhancing ascorbyl palmitate stability that could be used to support antioxidant network in the skin.

Jezik:Angleški jezik
Ključne besede:mikroemulzije, stabilnost, askorbil palmitat, keratinociti
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 1485-1492
Številčenje:Vol. 11, no. 3
UDK:542+66.02
ISSN pri članku:1530-9932
DOI:10.1208/s12249-010-9507-8 Povezava se odpre v novem oknu
COBISS.SI-ID:2877553 Povezava se odpre v novem oknu
Število ogledov:545
Število prenosov:74
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Gradivo je del revije

Naslov:AAPS PharmSciTech
Skrajšan naslov:AAPS PharmSciTech
Založnik:American Association of Pharmaceutical Scientists
ISSN:1530-9932
COBISS.SI-ID:1247345 Novo okno

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