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Application of 14N NQR to the study of sulfanilamide, piroxicam, and nifedipine polymorphism
Lavrič, Zoran (Avtor), Pirnat, Janez (Avtor), Lužnik, Janko (Avtor), Seliger, Janez (Avtor), Žagar, Veselko (Avtor), Trontelj, Zvonko (Avtor), Srčič, Stanko (Avtor)

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Izvleček
14N NQR is a new method in pharmacy that has a potential to establish itself as an additional and valuable analytical tool for characterizing solid state of a substance [1]. 14N NQR is a method that can precisely and accurately determine a specific polymorphic state of a solid compound. It is non-destructive and there is usually no spectral interference from other polymorphs or other solids. The objective of presented study was to use 14N NQR as a way to characterize qualitatively and quantitatively different solid state forms of sulfanilamide, nifedipine and piroxicam [3]. Thermodynamically stable forms of said substances were obtained on the market. Subsequently, samples of unstable amorphous or polymorphic forms were prepared. DSC and ATR FT-IR were used additionally to identify differences between the samples. 14N NQR method was used with the same samples to (re)confirm the already established polymorphic states [3]. 14N NQR method proved itself capable of accurately and precisely determining the solid-state forms of studied pure compounds. The possibility of accurately determining the mixture composition of different forms was also demonstrated. Mixtures of piroxicam forms in different ratios were prepared and then measured with 14N NQR. Determined mixture ratios were in close agreement with the known values.

Jezik:Angleški jezik
Ključne besede:14N NQR, nifedipin, piroksikam
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.12 - Objavljeni povzetek znanstvenega prispevka na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:Str. 714
UDK:542:615
ISSN pri članku:0036-8709
COBISS.SI-ID:2862961 Povezava se odpre v novem oknu
Število ogledov:536
Število prenosov:156
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del zbornika

Naslov:Abstracts of the 8th Central European Symposium on Pharmaceutical Technology (CESPT), Satellite Symposium: 4th International Graz Congress on Pharmaceutical Engineering, September 16th-18th, Graz, Austria
COBISS.SI-ID:2845297 Povezava se odpre v novem oknu

Gradivo je del revije

Naslov:Scientia Pharmaceutica
Skrajšan naslov:Sci. Pharm.
Založnik:Oesterreichische Apotheker-Verlagsgesellschat MBH
ISSN:0036-8709
COBISS.SI-ID:26371584 Povezava se odpre v novem oknu

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