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Furosemide-loaded microcapsules: the influence of lactose content on encapsulation efficiency and drug release
Zvonar Pobirk, Alenka (Avtor), Gosenca Matjaž, Mirjam (Avtor), Gašperlin, Mirjana (Avtor)

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Izvleček
In recent years there has been increasing attention given to the utility of selfmicroemulsifying systems (SMES) for improving the gastrointestinal absorption of drugs with inadequate biopharmaceutical properties. Microencapsulation of those systems into polymeric matrix is one of the solidification techniques that allow formulation of solid self-microemulsifingformulations. Microcapsules with furosemide-loaded self-microemulsifying core that merge the advantages of SMES with those of solid dosage forms where produced by co-extrusion of liquid jet by vibrating nozzle device. The composition of selfmicroemulsifying core was optimized previously [1]; the aim of this study was therefore to modify the shell-forming phase in order to gain repeatable production of microcapsules with high encapsulation efficiency. The influence of lactose content in microcapsules` shell on drug release profile from dried microcapsules and their swelling and erosion behaviour was examined additionally. Best shaped microcapsules with highest encapsulation efficiency were obtained from the shell-forming phase with the Ca-alginate/pectinate ratio of 1/3 containing 5-10% lactose [2]. Incorporation of furosemide in self-emulsifying core of microcapsules resulted in considerably enhanced drug release profile when compared to reference microspheres, which did not contain SMES. Drug release from microcapsules containing different content of lactose was further affected not only by pore inducing effect of lactose but also by the formationof hydrated visocous layer around the capsules, which acted as a barrier to drug release. The presented results constitute a step cloaser to a repeatable production of microcapsules with self-microemulsifying core by using method of liquid jet co-extrusion by vibrating nozzle device. Better solubility and permeability properties obtained with self-microemulsifying core also provide a promising alternative to ensure succesfull oral delivery of drugs with poor biopharmaceutical properties.

Jezik:Angleški jezik
Ključne besede:SMES, kalcijev alginat, mikrokapsule
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.12 - Objavljeni povzetek znanstvenega prispevka na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:Str. 605
UDK:542
ISSN pri članku:0036-8709
COBISS.SI-ID:2860145 Povezava se odpre v novem oknu
Število ogledov:774
Število prenosov:132
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del zbornika

Naslov:Abstracts of the 8th Central European Symposium on Pharmaceutical Technology (CESPT), Satellite Symposium: 4th International Graz Congress on Pharmaceutical Engineering, September 16th-18th, Graz, Austria
COBISS.SI-ID:2845297 Povezava se odpre v novem oknu

Gradivo je del revije

Naslov:Scientia Pharmaceutica
Skrajšan naslov:Sci. Pharm.
Založnik:Oesterreichische Apotheker-Verlagsgesellschat MBH
ISSN:0036-8709
COBISS.SI-ID:26371584 Povezava se odpre v novem oknu

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