izpis_h1_title_alt

Metal cation-fluoroquinolone complexes do not permeate through the intestinal absorption barrier
Žakelj, Simon (Avtor), Berginc, Katja (Avtor), Uršič, Darko (Avtor), Veber, Marjan (Avtor), Kristl, Albin (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=ArticleListURL&_method=list&_ArticleListID=1461805445&_st=13&view=c&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=8900c036607bb3225129a9c509b2f5ce&searchtype=a Povezava se odpre v novem oknu

Izvleček
A case of a clinically significant interaction between a fluoroquinolone antimicrobial agent and metal cations was first reported in 1985. The hypothesized mechanism - decreased fluoroquinolone intestinal permeability due to complex formation between metal cations and ciprofloxacin - was based ona 1978 work with nalidixic acid. While clinical research and numerous in vitro physico-chemical and chelation chemistry studies of fluoroquinolone-metal cation combinations simply accepted this explanation, the few in vitro studies, which were aimed to investigate the nature of the interaction mechanism, provided conflicting results. This was most likely due to the sensitivity of the interaction to in vivo conditions, which were not reproduced in vitro. All the above-mentioned studies including our earlier work in vitro were performed with diluted solutions of fluoroquinolones and metal cations. Now we provide results obtained on rat intestine in side-by-side diffusion chambers with saturated solutions of fluoroquinolones and metal cations in the donor compartment as it is most likely in the human small intestine in vivo. The fluoroquinolone permeability decreased under these conditions in the presence of metal cations and the obtained results show that the ciprofloxacin-aluminum complex does not permeate the intestinal mucosal membrane.

Jezik:Angleški jezik
Ključne besede:fluorkinoloni, permeabilnost, interakcije, protivnetna zdravila
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 655-659
Številčenje:Vol. 53, iss. 3
UDK:615.2
ISSN pri članku:0731-7085
DOI:10.1016/j.jpba.2010.05.021 Povezava se odpre v novem oknu
COBISS.SI-ID:2854257 Povezava se odpre v novem oknu
Število ogledov:540
Število prenosov:169
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Journal of pharmaceutical and biomedical analysis
Skrajšan naslov:J. pharm. biomed. anal.
Založnik:Pergamon Press
ISSN:0731-7085
COBISS.SI-ID:6557447 Povezava se odpre v novem oknu

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj