izpis_h1_title_alt

Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate
Pavli, Matej (Avtor), Vrečer, Franc (Avtor), Baumgartner, Saša (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7W-50THXC8-4&_user=4776866&_coverDate=08%2F19%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=e86fa5ac9ebf95737193b61a6f37766b&searchtype=a Novo okno

Izvleček
The use of polymeric polyelectrolytes as previous termmatrixnext term-forming agents is far from optimally or fully understood. Polyelectrolyte carrageenan (CARR) previous termmatricesnext term loaded with oppositely charged active substance doxazosin mesylate (DM) were investigated according to their water-uptake/erosion properties, in situ complexation ability of CARR with DM, and the possibility to achieve dual drug release control. Interactions between different CARR types (?-, ?-, and ?-) and DM were confirmed by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and zeta potential measurements. Combination of water-uptake/erosion with in situ complexation prolonged DM release from CARR previous termmatricesnext term for more than 24 h. The rate order of drug release was in accordance with the number of ester sulfate moieties per disaccharide unit of CARRs (? (1) > ? (2) > ? (3)). The higher the charge on the CARR backbone, the higher the number of interactions with DM and the slower the drug release. Low pH, more vigorous hydrodynamics, and higher ionic strength resulted in faster drugrelease. Based on zeta potential measurements of DM and CARRs, proposed influence of counterion condensation and its effect on screening polyelectrolyte-drug interactions was confirmed to lower in situ DM-CARR complexation. Dual drug release control from polyelectrolyte previous termmatricesnext term by water-uptake/erosion and in situ complexation offers many new approaches for designing controlled-release systems.

Jezik:Angleški jezik
Ključne besede:matrične tablete, priprava, metode
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 15-23
Številčenje:vol. 400, iss. 1-2
UDK:66
ISSN pri članku:0378-5173
DOI:10.1016/j.ijpharm.2010.08.021 Povezava se odpre v novem oknu
COBISS.SI-ID:2844017 Povezava se odpre v novem oknu
Število ogledov:393
Število prenosov:60
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
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Gradivo je del revije

Naslov:International journal of pharmaceutics
Skrajšan naslov:Int. j. pharm.
Založnik:Elsevier/North-Holland
ISSN:0378-5173
COBISS.SI-ID:3087631 Novo okno

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