izpis_h1_title_alt

Rational laboratory diagnostics of antiphospholipid antibodies: anti-cardiolipin, anti-ß2-glycoprotein I, anti-prothrombin and anti-annexin V antibodies
Božič, Borut (Avtor), Čučnik, Saša (Avtor), Gašperšič, Nataša (Avtor), Ambrožič, Aleš (Avtor), Kveder, Tanja (Avtor), Rozman, Blaž (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.ifcc.org/index.asp?cat=Publications&scat=eJIFCC_&suba=Vol_20_No_4&zip=1&dove=1&numero=327 Povezava se odpre v novem oknu

Izvleček
A possible co-appearance of anticardiolipin (aCL), anti ß2-glycoprotein I (anti-ß2-GPI), anti-prothrombin (aPT) and anti-annexin V (aANXV) antibodies of IgG, IgM and IgA class were studied in 58 patients with SLE alone and 32 patients APS in the view of rational laboratory diagnostics. The presence of anti-phospholipid antibodies (aPL) were defined by our in-house ELISA methods. Out of 17 aCL negative SLE patients 6 had other antigenically defined aPL antibodies. In 13 patients only IgA but not IgG and IgM anti ß2-GPI were detected. Different combinations of aPL subsets were equally distributed in APS and SLE groups. The prevalence of aANXV were similar in APSand SLE patients which was not the case with other aPL. Our findings support the idea of measuring additional subsets of aPL (aPT and aANXV) in unclear cases. IgA (either aCL or anti-ß2-GPI) improved neither the diagnostic specificity nor diagnostic sensitivity, but only increased the frequency of the total anti-ß2-GPI

Jezik:Angleški jezik
Ključne besede:laboratorijska diagnostika, anti-ß2-glikoproteini, anti-tromibini, anti-aneksini, protitelesa
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2009
Št. strani:str. 1-8
Številčenje:Vol. 20, no. 4
UDK:616-097
ISSN pri članku:1051-2292
COBISS.SI-ID:2798449 Povezava se odpre v novem oknu
Število ogledov:495
Število prenosov:145
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Journal of the International Federation of Clinical Chemistry
Skrajšan naslov:J. Int. Fed. Clin. Chem.
Založnik:Published by International Scientific Communications for the Federation
ISSN:1051-2292
COBISS.SI-ID:7192325 Povezava se odpre v novem oknu

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj