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Glutamate dehydrogenase activity in leukocytes and ageing
Kravos, Matej
(
Avtor
),
Malešič, Ivan
(
Avtor
)
URL - Predstavitvena datoteka, za dostop obiščite
http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000273582
Izvleček
Background: Glutamate dehydrogenase (GLDH) is an intracellular enzyme normally located in mitochondria and the rough endoplasmic reticulum. The metabolism of neuroexcitotoxic glutamate is lowered in many neurodegenerative disorders. Objective: Defining the GLDH activity in leukocytes can provide indirect data about neurodegenerative processes in the brain. Method: We have developed our own method of defining the GLDH activity in leukocytes. Results:The GLDH activity was researched in the leukocytes of 130 healthy subjects (45 females, 85 males). The mean catalytic activity was 0.618 0.380 kat/g. The highest values were discovered in <30-year-old persons: 0.772 0.434 kat/g (0.712 0.406 kat/g in men, 0.934 0.5 kat/g in women). The GLDH activity decreases more slowly in the 30- to 60-year age group, yet evidently more rapidly afterwards, particularly in men, where the activity drops to 0.333 kat/g and in women to 0.414 kat/g. The older personshad a lower leukocyte GLDH activity than the younger ones (ANOVA, p = 0.000). Conclusion: Gradual decrease in GLDH activity may be one of the key factors for neurodegenerative ageing processes.
Jezik:
Angleški jezik
Ključne besede:
glutamat
,
GLDH
,
staranje
,
levkociti
,
metabolizem
Vrsta gradiva:
Delo ni kategorizirano (r6)
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
Leto izida:
2010
Št. strani:
str. 239-242
Številčenje:
Vol. 7, no. 4
UDK:
612
ISSN pri članku:
1660-2854
DOI:
10.1159/000273582
COBISS.SI-ID:
2782321
Število ogledov:
807
Število prenosov:
216
Metapodatki:
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(0 glasov)
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Gradivo je del revije
Naslov:
Neurodegenerative diseases
Skrajšan naslov:
Neurodegener. dis.
Založnik:
S. Karger
ISSN:
1660-2854
COBISS.SI-ID:
514940697
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