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Glutamate dehydrogenase activity in leukocytes and ageing
Kravos, Matej (Author), Malešič, Ivan (Author)

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Abstract
Background: Glutamate dehydrogenase (GLDH) is an intracellular enzyme normally located in mitochondria and the rough endoplasmic reticulum. The metabolism of neuroexcitotoxic glutamate is lowered in many neurodegenerative disorders. Objective: Defining the GLDH activity in leukocytes can provide indirect data about neurodegenerative processes in the brain. Method: We have developed our own method of defining the GLDH activity in leukocytes. Results:The GLDH activity was researched in the leukocytes of 130 healthy subjects (45 females, 85 males). The mean catalytic activity was 0.618 0.380 kat/g. The highest values were discovered in <30-year-old persons: 0.772 0.434 kat/g (0.712 0.406 kat/g in men, 0.934 0.5 kat/g in women). The GLDH activity decreases more slowly in the 30- to 60-year age group, yet evidently more rapidly afterwards, particularly in men, where the activity drops to 0.333 kat/g and in women to 0.414 kat/g. The older personshad a lower leukocyte GLDH activity than the younger ones (ANOVA, p = 0.000). Conclusion: Gradual decrease in GLDH activity may be one of the key factors for neurodegenerative ageing processes.

Language:English
Keywords:glutamat, GLDH, staranje, levkociti, metabolizem
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2010
Number of pages:str. 239-242
Numbering:Vol. 7, no. 4
UDC:612
ISSN on article:1660-2854
DOI:10.1159/000273582 Link is opened in a new window
COBISS.SI-ID:2782321 Link is opened in a new window
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Downloads:221
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Record is a part of a journal

Title:Neurodegenerative diseases
Shortened title:Neurodegener. dis.
Publisher:S. Karger
ISSN:1660-2854
COBISS.SI-ID:514940697 This link opens in a new window

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