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Glutamate dehydrogenase activity in leukocytes and ageing
Kravos, Matej (Avtor), Malešič, Ivan (Avtor)

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Izvleček
Background: Glutamate dehydrogenase (GLDH) is an intracellular enzyme normally located in mitochondria and the rough endoplasmic reticulum. The metabolism of neuroexcitotoxic glutamate is lowered in many neurodegenerative disorders. Objective: Defining the GLDH activity in leukocytes can provide indirect data about neurodegenerative processes in the brain. Method: We have developed our own method of defining the GLDH activity in leukocytes. Results:The GLDH activity was researched in the leukocytes of 130 healthy subjects (45 females, 85 males). The mean catalytic activity was 0.618 0.380 kat/g. The highest values were discovered in <30-year-old persons: 0.772 0.434 kat/g (0.712 0.406 kat/g in men, 0.934 0.5 kat/g in women). The GLDH activity decreases more slowly in the 30- to 60-year age group, yet evidently more rapidly afterwards, particularly in men, where the activity drops to 0.333 kat/g and in women to 0.414 kat/g. The older personshad a lower leukocyte GLDH activity than the younger ones (ANOVA, p = 0.000). Conclusion: Gradual decrease in GLDH activity may be one of the key factors for neurodegenerative ageing processes.

Jezik:Angleški jezik
Ključne besede:glutamat, GLDH, staranje, levkociti, metabolizem
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 239-242
Številčenje:Vol. 7, no. 4
UDK:612
ISSN pri članku:1660-2854
DOI:10.1159/000273582 Povezava se odpre v novem oknu
COBISS.SI-ID:2782321 Povezava se odpre v novem oknu
Število ogledov:700
Število prenosov:189
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Neurodegenerative diseases
Skrajšan naslov:Neurodegener. dis.
Založnik:S. Karger
ISSN:1660-2854
COBISS.SI-ID:514940697 Povezava se odpre v novem oknu

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