izpis_h1_title_alt

C-type lectin DC-SIGN; an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity
Švajger, Urban (Avtor), Anderluh, Marko (Avtor), Jeras, Matjaž (Avtor), Obermajer, Nataša (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2M-4YRXD4F-3&_user=4776866&_coverDate=10%2F31%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=ed5d13d6f812d844c82de952f66f809f&searchtype=a Povezava se odpre v novem oknu

Izvleček
The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen-presenting cells (APCs), the dendritic cells (DCs). In recent years, DC-SIGN has gained an exponential increase in attention because of its involvement in multiple aspects of immune function. Besides being an adhesion molecule, particularly in binding ICAM-2 and ICAM-3,it is also crucial in recognizing several endogenous and exogenous antigens. Additionally, the intracellular domain of DC-SIGN includes molecular motifs, which enable the activation of signal transduction pathways involving Raf-1 and subsequent modulation of DC-maturation status, through direct modification of nuclear factor Nf-?B in DCs. Upon DC-SIGN engagement bymannose- or fucose-containing oligosaccharides, the latter leads to a tailored Toll-like receptor signalling, resulting in an altered DC-cytokine profile and skewing of Th1/Th2 responses. In this article, we will discuss recent advances on a broad perspective concerning DC-SIGN structure, signalling and immune function.

Jezik:Angleški jezik
Ključne besede:dendritične celice, imunsko modeliranje, patogenski receptorji, adhezija, migracije
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 1397-1405
Številčenje:Vol. 22, iss. 10
UDK:577
ISSN pri članku:0898-6568
DOI:10.1016/j.cellsig.2010.03.018 Povezava se odpre v novem oknu
COBISS.SI-ID:2770545 Povezava se odpre v novem oknu
Število ogledov:587
Število prenosov:160
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Cellular signalling
Skrajšan naslov:Cell. signal.
Založnik:Pergamon Press.
ISSN:0898-6568
COBISS.SI-ID:21754585 Povezava se odpre v novem oknu

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj