izpis_h1_title_alt

MTHFR and TYMS genotypes influence TPMT activity and its differential modulation in males and females
Karas Kuželički, Nataša (Avtor), Milek, Miha (Avtor), Mlinarič-Raščan, Irena (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TDD-4X6MSYT-1&_user=4776866&_coverDate=01%2F31%2F2010&_rdoc=5&_fmt=high&_orig=browse&_srch=doc-info%28%23toc%235196%232010%23999569998%231578386%23FLA%23display%23Volume%29&_cdi=5196&_sort=d&_docanchor=&_ct=31&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=8719625a02915f070092a63cb60de36d Povezava se odpre v novem oknu

Izvleček
Objectives: TPMT catalyzes the deactivation of the cytostatic drug 6-mercaptopurine used in treatment of cancer. Patients with low levels of TPMTmore often experience severe toxic effects when treated with standard doses of 6-mercaptopurine than patients with high levels who, in turn, may experience inadequate treatment. It is therefore very important to assess factors that could influence TPMT activity. Design and methods: Red blood cellTPMT activity was measured by means of HPLC and genotypes of 86 healthy individuals were analyzed using TaqMan and PCR-RFLP methods, in order to investigate the effect of TPMT, MTHFR and TYMS genotypes on TPMT activity. Results: TPMT activity was higher in TPMT wild-type males than females (p=0.028). Three-way ANOVA interaction analysis revealed a significant interaction effect between MTHFR genotype and gender on TPMT activity (p=0.023). Conclusion: Males have higher TPMT activity than females and the trend of influence of MTHFR genotype on TPMT activity is different in the two gender groups.

Jezik:Angleški jezik
Ključne besede:farmakogenetika, TPMT, TYMS
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 37-42
Številčenje:Vol. 43, no. 1-2
UDK:577.2
ISSN pri članku:0009-9120
COBISS.SI-ID:2739825 Povezava se odpre v novem oknu
Število ogledov:451
Število prenosov:102
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Clinical biochemistry
Skrajšan naslov:Clin. biochem.
Založnik:Elsevier.
ISSN:0009-9120
COBISS.SI-ID:22275033 Povezava se odpre v novem oknu

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj