izpis_h1_title_alt

Dendritic cells treated with resveratrol during differentiation from monocytesgain substantial tolerogenic properties upon activation
Švajger, Urban (Avtor), Obermajer, Nataša (Avtor), Jeras, Matjaž (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www3.interscience.wiley.com/journal/123191679/abstract Novo okno

Izvleček
Resveratrol is a polyphenol that acts on multiple molecular targets important for cell differentiation and activation. Dendritic cells (DCs) are a functionally diverse cell type and represent the most potent antigen-presenting cells of the immune system. In this study, we investigated resveratrol-induced effects on DCs during their differentiation and maturation. Our results show that resveratrol induces DC-associated tolerance,particularly when applied during DC differentiation. Costimulatory molecules CD40, CD80 and CD86 were down-regulated, as was the expression of major histocompatibility complex (MHC) class II molecules. Surface expression of inhibitory immunoglobulin-like transcript 3 (ILT3) and ILT4 molecules was induced, while human leucocyte antigen (HLA)-G expression was not affected. Resveratrol-treated DCs lost the ability to produce interleukin (IL)-12p70 after activation, but had an increased ability to produce IL-10. Such DCs werepoor stimulators of allogeneic T cells and had lowered ability to induce CD4+ T-cell migration. Furthermore, treated cells were able to generate allogeneic IL-10-secreting T cells, but were not competent in inducing FoxP3 expression These tolerogenic effects are probably associated with the effect of resveratrol on multiple molecular targets through which it interferes with DC differentiation and nuclear factor (NF)-?B translocation. Our data provide new insights into the molecular and functional mechanisms of the tolerogenic effects that resveratrol exerts on DCs.

Jezik:Angleški jezik
Ključne besede:imunsko modeliranje, regulatorne T celice, resveratrol, toleranca, dendritične celice
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str.525-535
Številčenje:Vol. 129, Issue 4
UDK:577
ISSN pri članku:0019-2805
DOI:10.1111/j.1365-2567.2009.03205.x Povezava se odpre v novem oknu
COBISS.SI-ID:2729841 Povezava se odpre v novem oknu
Število ogledov:637
Število prenosov:136
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na: Bookmark and Share

Gradivo je del revije

Naslov:Immunology
Skrajšan naslov:Immunology
Založnik:Blackwell Scientific Publications
ISSN:0019-2805
COBISS.SI-ID:49943 Novo okno

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj