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The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol
Teskač, Karmen (Avtor), Kristl, Julijana (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T7W-4XFGJC4-3-N&_cdi=5069&_user=4776866&_orig=search&_coverDate=10%2F13%2F2009&_sk=999999999&view=c&wchp=dGLbVzz-zSkWA&md5=7d350c8401751a5eba05d7f08986fef4&ie=/sdarticle.pdf Novo okno

Izvleček
The potential for colloidal carriers to increase drug bioavailability has spurred a renewed interest in their uptake mechanisms and movement within cells. Solid lipid nanoparticles (SLN) were used as a carrier for a promising chemopreventive drug, resveratrol (RSV). The effects of SLN, empty or loaded with RSV (SLN-RSV), on the internalization, growth, morphology, metabolic activity and genetic material of keratinocytes were compared to those of RSV in solution. Fluorescence images clearly showed that SLN with a size below 180 nm move promptly through the cell membrane, distribute throughout the cytosol, move successively among different cellular levels and localize in the perinuclear region without inducing cytotoxicity. RSV solubility, stability and intracellular delivery were all increased by loading into SLN. The release profile of RSV showed a biphasic pattern, reflecting its distribution in SLN. RSV in solution was slightly cytotoxic. That was prevented by loading it into solid lipid nanoparticles, which preserved cell morphology. The cytostatic effect of SLN-RSV was much more expressed than that of RSV in solution. Delivery of RSV by SLN contributes to effectiveness of RSV on decreasing cell proliferation, with potential benefits for prevention of skin cancer.

Jezik:Angleški jezik
Ključne besede:resveratrol, nanodelci, nanomedicina, celične membrane, kontrolirano sproščanje
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 61-69
Številčenje:Vol. 390, Issue 1
UDK:542+543
ISSN pri članku:0378-5173
DOI:10.1016/j.ijpharm.2009.10.011 Povezava se odpre v novem oknu
COBISS.SI-ID:2708337 Povezava se odpre v novem oknu
Število ogledov:422
Število prenosov:123
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:International journal of pharmaceutics
Skrajšan naslov:Int. j. pharm.
Založnik:Elsevier/North-Holland
ISSN:0378-5173
COBISS.SI-ID:3087631 Novo okno

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