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Glutamate dehydrogenase as a marker of alcohol dependence
Kravos, Matej (Author), Malešič, Ivan (Author)

URLURL - Presentation file, Visit http://alcalc.oxfordjournals.org/cgi/content/abstract/agp070 This link opens in a new window

Abstract
Aims: The aim of this study was to examine glutamate dehydrogenase (GLDH) in the diagnostic combinations as a result of new findings. Methods: GLDH, gama-glutamyltransferase (GGT), aspartate-aminotranferase (AST), alanine-aminotransferase (ALT) and erythrocyte mean cell volume (MCV) were assessed three times in 238 alcoholics admitted to hospital: on admission, after 24 h and after 7 days. Results: All the values were significantly higher than those in healthy persons. The fastest activity decrease was seen in GLDH. The kinetics of GLDH and AST were more applicable than GGT kinetics after a week, but GLDH kinetics were most reliable. GLDH was the most specific laboratory marker with almost 90% specificity. The sensitivity of combination MCV and GLDH kinetics after 1 week of abstinence was pathognomonic by 97.2%. This decision tree gave us a model with 84.5% accuracy.Conclusions: GLDH is an equally accurate marker of alcoholism in comparison to others, if its significantly faster decrease is taken into consideration. We strongly believe that watching changes in the activity of laboratory markers of alcoholism is an effective yet overlooked aid.

Language:English
Keywords:glutamat dehidrogenaze, alkoholizem, metode, diagnostika
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2010
Number of pages:str. 39-44
Numbering:Vol. 45, iss. 1
UDC:616
ISSN on article:0735-0414
DOI:0.1093/alcalc/agp070 Link is opened in a new window
COBISS.SI-ID:2707057 Link is opened in a new window
Views:1000
Downloads:171
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Record is a part of a journal

Title:Alcohol and alcoholism
Shortened title:Alcohol alcohol.
Publisher:Pergamon
ISSN:0735-0414
COBISS.SI-ID:2512404 This link opens in a new window

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