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Glutamate dehydrogenase as a marker of alcohol dependence
Kravos, Matej (Avtor), Malešič, Ivan (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://alcalc.oxfordjournals.org/cgi/content/abstract/agp070 Povezava se odpre v novem oknu

Izvleček
Aims: The aim of this study was to examine glutamate dehydrogenase (GLDH) in the diagnostic combinations as a result of new findings. Methods: GLDH, gama-glutamyltransferase (GGT), aspartate-aminotranferase (AST), alanine-aminotransferase (ALT) and erythrocyte mean cell volume (MCV) were assessed three times in 238 alcoholics admitted to hospital: on admission, after 24 h and after 7 days. Results: All the values were significantly higher than those in healthy persons. The fastest activity decrease was seen in GLDH. The kinetics of GLDH and AST were more applicable than GGT kinetics after a week, but GLDH kinetics were most reliable. GLDH was the most specific laboratory marker with almost 90% specificity. The sensitivity of combination MCV and GLDH kinetics after 1 week of abstinence was pathognomonic by 97.2%. This decision tree gave us a model with 84.5% accuracy.Conclusions: GLDH is an equally accurate marker of alcoholism in comparison to others, if its significantly faster decrease is taken into consideration. We strongly believe that watching changes in the activity of laboratory markers of alcoholism is an effective yet overlooked aid.

Jezik:Angleški jezik
Ključne besede:glutamat dehidrogenaze, alkoholizem, metode, diagnostika
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 39-44
Številčenje:Vol. 45, iss. 1
UDK:616
ISSN pri članku:0735-0414
DOI:0.1093/alcalc/agp070 Povezava se odpre v novem oknu
COBISS.SI-ID:2707057 Povezava se odpre v novem oknu
Število ogledov:920
Število prenosov:152
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Gradivo je del revije

Naslov:Alcohol and alcoholism
Skrajšan naslov:Alcohol alcohol.
Založnik:Pergamon
ISSN:0735-0414
COBISS.SI-ID:2512404 Povezava se odpre v novem oknu

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