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Effects of high-fat mixed-lipid diet and exercise on the antioxidant system inskeletal and cardiac muscles of rats with colon carcinoma
Perše, Martina (Avtor), Injac, Rade (Avtor), Štrukelj, Borut (Avtor), Cerar, Anton (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.if-pan.krakow.pl/pjp/cont09.html#No5 Novo okno

Izvleček
Epidemiological and experimental studies suggest that eating habits and a sedentary lifestyle play a critical role in the incidence of colon carcinoma. In order to investigate the effects of high-fat mixed-lipid (HFML) diet in conjunction with long-term swimming, the antioxidant capacity of skeletal and cardiac muscles were observed in rats with 1,2-dimethylhydrazine (DMH)-inducedcolon carcinoma. MaleWistar rats were randomly divided into one control group and four cancer groups: sedentary and swimming groups fed low fat corn oil diet and sedentary and swimming groups, fed a HFMLdiet. After 6 months of swimming, rats were sacrificed and the blood, cardiac and soleus muscle were taken for analysis. Serum cholesterol, triglyceride and glucose concentrations were measured and the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase as well as levels of malondialdehyde and glutathione were determined. The results showed that endurance swimming prevented lipid peroxidation in the soleus muscle of HFML diet rats due to elevated activities of antioxidant enzymes. On the other hand, increased lipid peroxidation in the hearts of all cancer groups indicated that DMH-induced colon carcinoma impaired the antioxidant status of the heart. This failure in heart tissue indicated that enhanced antioxidant capacity after regular physical activity is not sufficient to offset oxidative stress caused by DMH-induced colon carcinoma.

Jezik:Angleški jezik
Ključne besede:oksidativni stres, antioksidanti, telesna aktivnost, rak debelega črevesa
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2009
Št. strani:str. 909-916
Številčenje:Vol. 61, no. 5
UDK:612
ISSN pri članku:1734-1140
COBISS.SI-ID:2701681 Povezava se odpre v novem oknu
Število ogledov:510
Število prenosov:89
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Pharmacological Reports
Skrajšan naslov:Pharmacol. Rep.
Založnik:Institute of Pharmacology Polish Academy of Sciences
ISSN:1734-1140
COBISS.SI-ID:2429041 Novo okno

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