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Improvements of cellular stress response on resveratrol in liposomes
Kristl, Julijana (Avtor), Teskač, Karmen (Avtor), Caddeo, Carla (Avtor), Abramović, Zrinka (Avtor), Šentjurc, Marjeta (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6C-4WHFD4M-1&_user=4776866&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=cfd331b234d9111b2395f93195e7ee33 Novo okno

Izvleček
Resveratrol (RSV) has proven potential in prophylaxis and treatment of variousdisorders mediated by free radicals and oxidative stress. RSV solubility, stability, and cytotoxicity must be regulated for satisfactory bioavailability. Here, RSV was loaded into liposomes, characterized by PCS andTEM and evaluated on HEK293 cell line by metabolic activity assay, electronparamagnetic resonance, and fluorescence microscopy. RSV at 10 ?M induced changes in cell metabolic activity and significantly improved antioxidative capacity. At 100 ?M it showed concentration-dependent cytotoxicity. Oligolamellar liposomes with mean diameter 84 nm, polydispersityindex 0.2, and zeta potential -40 mV showed high entrapment of RSV and rapid cellular internalization. Cell stress caused by UV-B irradiationdiminished cell metabolic activity by 50%. RSV loaded into them showed no cytotoxicity at 100 ?M and stimulated cellular metabolic and antioxidant activity levels to eliminate the harmful effect of the stress. Localization of RSV within liposomal bilayer is crucial for stimulation of cell-defense system, prevention of RSV cytotoxicity, and its long-term stability. In summary, evidence of different metabolic activity using free RSVand LIP-RSV is presented indicating that liposome-mediated uptake of RSV ismore effective for improvement of the cell-stress response.

Jezik:Angleški jezik
Ključne besede:antioksidanti, resveratrol, prosti radikali, liposomi
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2009
Št. strani:str. 253-259
Številčenje:Vol. 73, no. 2
UDK:542:615
ISSN pri članku:0939-6411
DOI:10.1016/j.ejpb.2009.06.006 Povezava se odpre v novem oknu
COBISS.SI-ID:2634097 Povezava se odpre v novem oknu
Število ogledov:492
Število prenosov:109
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:European journal of pharmaceutics and biopharmaceutics
Skrajšan naslov:Eur. j. pharm. biopharm.
Založnik:Wiss. Verl.-Ges.
ISSN:0939-6411
COBISS.SI-ID:13176839 Novo okno

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