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Inactivation of harmful tumour-associated proteolysis by nanoparticulate system
Kos, Janko (Avtor), Obermajer, Nataša (Avtor), Doljak, Bojan (Avtor), Kocbek, Petra (Avtor), Kristl, Julijana (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T7W-4W741YW-1-F&_cdi=5069&_user=4776866&_orig=browse&_coverDate=11%2F03%2F2009&_sk=996189997&view=c&wchp=dGLbVlW-zSkzV&md5=5d3e34a682e16f870c88cdc177e8a4f7&ie=/sdarticle.pdf Povezava se odpre v novem oknu

Izvleček
The primary aim in cancer therapy is to deliver anti-cancer drugs to their specific molecular targets in the tumour. Here we present a systemcomposed of poly(d,l-lactide-co-glycolide) nanoparticles, cytokeratin specific monoclonal antibody and cystatin, a potent protease inhibitor, that can neutralize the excessive proteolytic activity associated with the invasive and metastatic potential of breast tumour cells. The antibody provides specific targeting of the delivery system to invasive breast epithelial cells and, additionally, prevents the generation of plasmin, a central extracellular protease involved in malignant progression. Polymeric nanoparticles rapidly enter the targeted cells and release the inhibitor cargo within the endosomes/lysosomes. The inhibitor is capable to inactivate lysosomal cysteine proteases, in particularcathepsin B, which is involved in the degradation of extracellular matrix inside the tumour cells. Our approach, which combines nanoparticulate delivery system with the inhibitory potential against extracellular and intracellular proteases, may improve the efficacy of therapy in patients with breast tumours compared to the application of individual protease inhibitors.

Jezik:Angleški jezik
Ključne besede:nanodelci, protitelesa, citokeratin, cistatin, plazmin, katepsin
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.08 - Objavljeni znanstveni prispevek na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2009
Št. strani:Str. 106-112
Številčenje:Vol. 381, no. 2
UDK:577.2
ISSN pri članku:0378-5173
DOI:10.1016/j.ijpharm.2009.04.037 Povezava se odpre v novem oknu
COBISS.SI-ID:2620785 Povezava se odpre v novem oknu
Število ogledov:379
Število prenosov:115
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Gradivo je del zbornika

Naslov:Challenges in Nano- Micro- and Macro-Systems
COBISS.SI-ID:2662769 Povezava se odpre v novem oknu

Gradivo je del revije

Naslov:International journal of pharmaceutics
Skrajšan naslov:Int. j. pharm.
Založnik:Elsevier/North-Holland
ISSN:0378-5173
COBISS.SI-ID:3087631 Povezava se odpre v novem oknu

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