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Inactivation of harmful tumour-associated proteolysis by nanoparticulate system
Kos, Janko (Author), Obermajer, Nataša (Author), Doljak, Bojan (Author), Kocbek, Petra (Author), Kristl, Julijana (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T7W-4W741YW-1-F&_cdi=5069&_user=4776866&_orig=browse&_coverDate=11%2F03%2F2009&_sk=996189997&view=c&wchp=dGLbVlW-zSkzV&md5=5d3e34a682e16f870c88cdc177e8a4f7&ie=/sdarticle.pdf This link opens in a new window

Abstract
The primary aim in cancer therapy is to deliver anti-cancer drugs to their specific molecular targets in the tumour. Here we present a systemcomposed of poly(d,l-lactide-co-glycolide) nanoparticles, cytokeratin specific monoclonal antibody and cystatin, a potent protease inhibitor, that can neutralize the excessive proteolytic activity associated with the invasive and metastatic potential of breast tumour cells. The antibody provides specific targeting of the delivery system to invasive breast epithelial cells and, additionally, prevents the generation of plasmin, a central extracellular protease involved in malignant progression. Polymeric nanoparticles rapidly enter the targeted cells and release the inhibitor cargo within the endosomes/lysosomes. The inhibitor is capable to inactivate lysosomal cysteine proteases, in particularcathepsin B, which is involved in the degradation of extracellular matrix inside the tumour cells. Our approach, which combines nanoparticulate delivery system with the inhibitory potential against extracellular and intracellular proteases, may improve the efficacy of therapy in patients with breast tumours compared to the application of individual protease inhibitors.

Language:English
Keywords:nanodelci, protitelesa, citokeratin, cistatin, plazmin, katepsin
Work type:Not categorized (r6)
Tipology:1.08 - Published Scientific Conference Contribution
Organization:FFA - Faculty of Pharmacy
Year:2009
Number of pages:Str. 106-112
Numbering:Vol. 381, no. 2
UDC:577.2
ISSN on article:0378-5173
DOI:10.1016/j.ijpharm.2009.04.037 Link is opened in a new window
COBISS.SI-ID:2620785 Link is opened in a new window
Views:401
Downloads:131
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Record is a part of a proceedings

Title:Challenges in Nano- Micro- and Macro-Systems
COBISS.SI-ID:2662769 This link opens in a new window

Record is a part of a journal

Title:International journal of pharmaceutics
Shortened title:Int. j. pharm.
Publisher:Elsevier/North-Holland
ISSN:0378-5173
COBISS.SI-ID:3087631 This link opens in a new window

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