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Aged garlic extract stimulates P-glycoprotein and multidrug resistance associated
Berginc, Katja (Author), Žakelj, Simon (Author), Uršič, Darko (Author), Kristl, Albin (Author)

URLURL - Presentation file, Visit https://www.jstage.jst.go.jp/article/bpb/32/4/32_4_694/_article This link opens in a new window

Abstract
The growing concomitant consumption of drugs and herbal preparations such as garlic, and the numerous reports about the influence of herbal preparations onintestinal transport, led us to evaluate the influence of aged garlic extract on the transport function and electrophysiological parameters of the small intestinal mucosa. Aged garlic extract induced increase of the absolute value of the transepithelial potential difference and of the short-circuit current in both permeability models tested (rat jejunum, Caco-2 cell monolayers) without affecting transepithelial electrical resistance. It also caused a significant increase of the Pgp and MRP-2 mediated effluxes through rat jejunum of marker substrates Rhodamine 123 and 2,4-dinitrophenyl-S-glutathione, respectively. Rhodamine 123 efflux through the Caco-2 cell monolayers was not altered by aged garlic extract, whereas theefflux of 2,4-dinitrophenyl-Sglutathione increased significantly. So altered activity of the important transport proteins could significantly change the pharmacokinetic properties of conventional medicines taken concomitantly with aged garlic extract.

Language:English
Keywords:česen, P-glikoprotein, MRP-2, metode
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2009
Number of pages:str. 694-699
Numbering:Vol. 32, no. 4
UDC:542.9+543
ISSN on article:0918-6158
COBISS.SI-ID:2506865 Link is opened in a new window
Views:294
Downloads:76
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Record is a part of a journal

Title:Biological & pharmaceutical bulletin
Shortened title:Biol. pharm. bull.
Publisher:Pharmacetical Society of Japan
ISSN:0918-6158
COBISS.SI-ID:504623 This link opens in a new window

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