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New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3
Štefane, Bogdan (Author), Brožič, Petra (Author), Vehovc, Matej (Author), Lanišnik-Rižner, Tea (Author), Gobec, Stanislav (Author)

URLURL - Presentation file, Visit http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VKY-4VJ4WGN-3&_user=4776866&_coverDate=02%2F05%2F2009&_alid=864087734&_rdoc=1&_fmt=high&_orig=search&_cdi=6135&_sort=d&_docanchor=&view=c&_ct=1&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=963a1f3ad2e7613342f96090e239e34b This link opens in a new window

Abstract
A series of cyclopentane derivatives was synthesized and evaluated for inhibition of the steroid metabolizing enzymes AKR1C1 and AKR1C3. Selective inhibitors that are active in the low micromolar range were identified. These compounds represent promising starting points in the development of new anticancer agents for the treatment of hormone-dependent forms of cancer and other diseases where AKR1C1 and AKR1C3 are involved.

Language:English
Keywords:AKR1C1 inhibitorji, AKR1C3 inhibitorji, ciklopentan, derivati, rak
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2009
Number of pages:str. 2563-2571
Numbering:Vol. 44, no. 6
UDC:543.057
ISSN on article:0223-5234
DOI:10.1016/j.ejmech.2009.01.028 Link is opened in a new window
COBISS.SI-ID:2505841 Link is opened in a new window
Views:413
Downloads:106
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Record is a part of a journal

Title:European journal of medicinal chemistry
Shortened title:Eur. j. med. chem.
Publisher:Elsevier
ISSN:0223-5234
COBISS.SI-ID:25429760 This link opens in a new window

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