izpis_h1_title_alt

Skin oxygenation after topical application of liposome-entrapped benzyl nicotinate as measured by EPR oximetry in vivo : influence of composition and size
Kristl, Julijana (Avtor), Abramović, Zrinka (Avtor), Šentjurc, Marjeta (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.aapspharmsci.org/volsIssues/issueView.asp?vol=05&issue=01 Novo okno

Izvleček
New and improved drug delivery systems are the important subject of much scientific research. The development of formulations that increase skin oxygenation and of methods for measuring oxygen levels in skin are important for dealing with healing processes affected by the level of oxygen. We have used EPR oximetry in vivo to compare the influence of liposomal formulations of different size and composition with that of hydrogel with respect to the action of the entrapped benzyl nicotinate (BN). Following the topical application of BN onto the skin of mice, 2 increase was measured by low-frequency EPR as a function of time. The effect of BN was evaluated by 3 different parametersČ lag-time, time needed for maximum increase, and overall effectiveness expressed by the area under the response-time curve. An increasein skin oxygenation was observed after BN application. The results show that the effect of BN incorporated in liposomes is achieved more rapidly than the effect from hydrophilic gel. The composition of the liposomes significantly affects the time at which BN starts to act and, to a lesser extent, the maximum increase of pO in skin and the effectiveness of BN action.However, the size of the liposomes influences both the effectiveness ofBN action and the time at which BN starts to act. After repeated applicationof liposomes, the pO baseline increased and the response of the skin tissue was faster. Our results demonstrate that EPR oximetry is a useful method for evaluating oxygen changes after drug application and for following the time course of their action

Jezik:Angleški jezik
Ključne besede:koža, EPR in vivo, liposomi
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2003
Št. strani:article 2, str. 19-27
Številčenje:vol. 5, no. 1
UDK:666.5
ISSN pri članku:1522-1059
COBISS.SI-ID:1242225 Povezava se odpre v novem oknu
Število ogledov:432
Število prenosov:79
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:#The #AAPS PharmSci
Skrajšan naslov:AAPS PharmSci
Založnik:American Association of Pharmaceutical Scientists
ISSN:1522-1059
COBISS.SI-ID:2028657 Novo okno

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