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Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma- enolase and impairs survival and neuritogenesis of neuronal cells
Obermajer, Nataša (Avtor), Doljak, Bojan (Avtor), Jamnik, Polona (Avtor), Pečar Fonović, Urša (Avtor), Kos, Janko (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TCH-4VSB1G0-1-Y&_cdi=5171&_user=4776866&_orig=search&_coverDate=09%2F30%2F2009&_sk=999589991&view=c&wchp=dGLbVzW-zSkWz&md5=fd42062dfc2bd60041848ef0e469f0f2&ie=/sdarticle.pdf Povezava se odpre v novem oknu

Izvleček
The cysteine carboxypeptidase cathepsin X has been recognized as an important player in degenerative processes during normal aging and in pathological conditions. In this study we identify isozymes alpha and gamma enolases as targets for cathepsin X. Cathepsin X sequentially cleaves C-terminal amino acids of both isozymes, abolishing their neurotrophic activity. Neuronal cell survival and neuritogenesis are, in this way, regulated, as shown on pheochromocytoma cell line PC12. Inhibition of cathepsin X activity increases generation of plasmin, essential for neuronal differentiation and changes the length distribution of neurites, especially in the early phase of neurite outgrowth. Moreover, cathepsin X inhibition increases neuronal survival and reduces serum deprivation induced apoptosis, particularly in the absence of nerve growth factor. On the other hand, the proliferation of cells is decreased, indicating induction of differentiation. Our study reveals enolase isozymes as crucial neurotrophic factors that are regulated by the proteolyticactivity of cathepsin X.

Jezik:Angleški jezik
Ključne besede:katepsin X, gama enolaze, inhibicija, proteolitična aktivnost
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2009
Št. strani:str. 1685-1696
Številčenje:Vol. 41, no. 8-9
UDK:577.2
ISSN pri članku:1357-2725
DOI:10.1016/j.biocel.2009.02.019 Povezava se odpre v novem oknu
COBISS.SI-ID:2520945 Povezava se odpre v novem oknu
Število ogledov:439
Število prenosov:113
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Naslov:International journal of biochemistry & cell biology
Skrajšan naslov:Int J Biochem Cell Biol
Založnik:Elsevier Science Ltd
ISSN:1357-2725
COBISS.SI-ID:1358612 Povezava se odpre v novem oknu

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