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Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma- enolase and impairs survival and neuritogenesis of neuronal cells
Obermajer, Nataša (Author), Doljak, Bojan (Author), Jamnik, Polona (Author), Pečar Fonović, Urša (Author), Kos, Janko (Author)

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Abstract
The cysteine carboxypeptidase cathepsin X has been recognized as an important player in degenerative processes during normal aging and in pathological conditions. In this study we identify isozymes alpha and gamma enolases as targets for cathepsin X. Cathepsin X sequentially cleaves C-terminal amino acids of both isozymes, abolishing their neurotrophic activity. Neuronal cell survival and neuritogenesis are, in this way, regulated, as shown on pheochromocytoma cell line PC12. Inhibition of cathepsin X activity increases generation of plasmin, essential for neuronal differentiation and changes the length distribution of neurites, especially in the early phase of neurite outgrowth. Moreover, cathepsin X inhibition increases neuronal survival and reduces serum deprivation induced apoptosis, particularly in the absence of nerve growth factor. On the other hand, the proliferation of cells is decreased, indicating induction of differentiation. Our study reveals enolase isozymes as crucial neurotrophic factors that are regulated by the proteolyticactivity of cathepsin X.

Language:English
Keywords:katepsin X, gama enolaze, inhibicija, proteolitična aktivnost
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2009
Number of pages:str. 1685-1696
Numbering:Vol. 41, no. 8-9
UDC:577.2
ISSN on article:1357-2725
DOI:10.1016/j.biocel.2009.02.019 Link is opened in a new window
COBISS.SI-ID:2520945 Link is opened in a new window
Views:459
Downloads:123
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Record is a part of a journal

Title:International journal of biochemistry & cell biology
Shortened title:Int J Biochem Cell Biol
Publisher:Elsevier Science Ltd
ISSN:1357-2725
COBISS.SI-ID:1358612 This link opens in a new window

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