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Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts
Zupan, Janja (Avtor), Jeras, Matjaž (Avtor), Marc, Janja (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.biochemia-medica.com/system/files/Zupan%20J.%20et%20al.-Osteoimmunology%20and%20pro-infl%20ammatory%20cytokines.pdf Povezava se odpre v novem oknu

Izvleček
Bone and immune system are functionally interconnected. Immune and bone cells derive from same progenitors in the bone marrow, they share a common micro environment and are being in" uenced by similar mediators. The evidence on increased bone resorption associated with inappropri- ate activation of T cells such as during inflammation, is well established. However, the molecular mechanisms beyond this clinical observation have begun to be intensively studied with the advancement of osteoimmunology. Now days, we have firm evidence on the influence of numerous proinflammatory cytokines on bone cells, with the majority of data focused on osteoclasts, the bone resorbing cells. It has been shown that some pro- inflammatory cytokines couldpossess osteoclastogenic and/or anti-osteoclastogenic properties and can target osteoclasts directly or via receptor activator of nuclear factor ŽB (RANK)/RANK ligand(RANKL)/osteoprotegerin (OPG) system. Several studies have reported opposing data regarding (anti)osteoclastogenic properties of these cytokines. Therefore, the $ rst part of this review is summarizing current evidence on the in" uence of pro-in" ammatory cytokines on osteoclasts and thus on bone resorption. In the second part, the evidence on the role of pro-inflammatory cytokines in osteoporosis and osteoarthritis is reviewed to show that unravelling the mechanisms beyond such complex bone diseases, is almost impossible without considering skeletal and immune systems as an indivisible integrated system.

Jezik:Angleški jezik
Ključne besede:osteoimunologija, citokini, osteoklasti, RANKL, osteoporoza
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2013
Št. strani:str. 43-63
Številčenje:Vol. 23, no 1
UDK:616-074+616.7
ISSN pri članku:1330-0962
DOI:10.11613/BM.2013.007 Povezava se odpre v novem oknu
COBISS.SI-ID:3391857 Povezava se odpre v novem oknu
Število ogledov:643
Število prenosov:121
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Biochemia medica
Skrajšan naslov:Biochem. med.
Založnik:Hrvatsko društvo medicinskih biokemičara
ISSN:1330-0962
COBISS.SI-ID:3502345 Povezava se odpre v novem oknu

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