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A compressibility and compactibility study of real tableting mixtures: the effect of granule particle size
Šantl, Maja (Author), Ilić, Ilija (Author), Vrečer, Franc (Author), Baumgartner, Saša (Author)

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Abstract
This study investigates the effect of particle size on the compression characteristics of wet- (fluid-bed granulation - FBG) and dry-granulated (slugging - DGS) tableting mixtures. Particle-size distribution, flowability, compressibility, using the Heckel and Walker model, compactibility and elastic recovery as well as friability and disintegration were determined and compared between the two particle size fractions (180400m, 400 710 micro) and initial unsieved mixtures. The results showed that the particle size of granules had no effect on the compressibility of the FBG and DGS mixtures, dueto the high fragmenting nature of the formulation used in this study. On the other hand, compactibility was particle size dependent, as larger-sized fractions showed higher crushing strength, lower friability, and lower elastic recovery. This was attributed to increased fragmentation of larger particles, allowing stronger bonding between uncontaminated surface areas. As a result of better rearrangement of particles, both initial tableting mixtures showed lower compressibility and lower compactibility compared to their sieved fractions.

Language:English
Keywords:farmacevtski praški, farmacevtska industrija, tablete, granuliranje
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2012
Number of pages:str. 325-340
Numbering:Vol. 62, no. 3
UDC:66.02+661.12
ISSN on article:1330-0075
DOI:10.2478/v10007-012-0028-8 Link is opened in a new window
COBISS.SI-ID:3299441 Link is opened in a new window
Views:431
Downloads:142
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Record is a part of a journal

Title:Acta pharmaceutica
Shortened title:Acta pharm.
Publisher:Hrvatsko farmaceutsko društvo
ISSN:1330-0075
COBISS.SI-ID:13497349 This link opens in a new window

Secondary language

Language:English
Abstract:
V študiji smo proučevali vpliv velikosti delcev na stisljivost vlažno (vrtinčnoslojno granuliranje - FBG) in suho (briketiranje - DGS) granuliranih zmesi za tabletiranje. Dvema velikostnima frakcijama vsake zmesi (180-400 micr, 400-710 micro) in primerjalno nepresejanima zmesema smo določili porazdelitev velikosti delcev, pretočnost, kompresibilnost z uporabo Heckelovega in Walkerjevega modela in kompaktibilnost. Tabletam izdelanim iz posameznih zmesismo določili dele elastične relaksacije, krušljivost in razpadnost. Rezultati naše študije potrjujejo, da velikost granulata ne vpliva na kompresibilnost FBG in DGS zmesi za tabletiranje, kar je posledica izrazite fragmentacijske narave uporabljene formulacije zmesi. V nasprotju s tem dejstvom pa je bil potrjen signifikanten vpliv velikosti delcev na kompaktibilnost, saj so imele tablete izdelane iz večjih velikostnih frakcij višjo natezno trdnost, nijo krušljivost in niji dele elastične relaksacije. To pripisujemo izrazitejši fregmentaciji večjih delcev in posledično tvorbi močnejših povezav med novonastalimi čistimi površnami delcev. Obe osnovni zmesi sta zaradi boljše za~etne prerazporeditve delcev izkazovali slabšo kompresibilnost in kompaktibilnost.


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