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Cathepsin X in serum from patients with colorectal cancer: relation to prognosis
Vižin, Tjaša (Avtor), Christensen, Ib Jarle (Avtor), Nielsen, Hans Jørgen (Avtor), Kos, Janko (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://versita.metapress.com/content/65w42w03260l5508/fulltext.pdf Povezava se odpre v novem oknu

Izvleček
Background. Up-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood. Enhanced secretion of pro-Cat X was observed in malignant processes, and therefore, the level of total serum Cat X rather than the active enzyme may better reflect the tumour status. Patients and methods. Seventy-seven patients with colorectal cancer (CRC) were included in a retrospective study. Blood samples were collected prior to therapy. Using ELISA, the values of total Cat X were measured in serum. Groups of healthy persons (n=77), patients with adenomas (n=77) and patients with non-neoplastic findings (n=77) were included. Results. Significant differences between the group of colorectal patients and the groups of healthy persons, adenoma patients and patients with non-malignant findings could not be shown (p=0.89). Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07-4.05, p=0.028). Conclusions. Total serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC. Increased serum levels of total CatX may reflect more aggressive tumour cell phenotypes and suggest the involvement of Cat X in processes involved in later stages of tumour progression.

Jezik:Angleški jezik
Ključne besede:cysteine cathepsins, cathepsin X, colorectal cancer, prognosis, serum biomarker
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2012
Št. strani:str. 207-212, II
Številčenje:Vol. 46, no. 3
UDK:577.1+616.35
ISSN pri članku:1318-2099
DOI:10.2478/v10019-012-0040-0 Povezava se odpre v novem oknu
COBISS.SI-ID:3297393 Povezava se odpre v novem oknu
Število ogledov:610
Število prenosov:171
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Povezava se odpre v novem oknu

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