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Key role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells
Obermajer, Nataša (Author), Kalinski, Pawel (Author)

URLURL - Presentation file, Visit http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429587/pdf/onci-1-762.pdf This link opens in a new window

Abstract
PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated attraction to cancer environment, providing convenient immunotherapeutic targets.

Language:English
Keywords:COX2, PGE2, human, cancer, myeloid-derived suppressor cells, immune dysfunction, immunotherapy, transplantation
Work type:Not categorized (r6)
Tipology:1.03 - Short Scientific Article
Organization:FFA - Faculty of Pharmacy
Year:2012
Number of pages:str. 762-764
Numbering:Vol. 1, no. 5
UDC:616-006-097
ISSN on article:2162-4011
DOI:10.4161/onci.19681 Link is opened in a new window
COBISS.SI-ID:3289969 Link is opened in a new window
Views:908
Downloads:216
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Secondary language

Language:English
Keywords:rak, imunska disfunkcija, imunoterapija, transplantacija

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