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Oxidative stress in schizophrenia
Bošković, Marija (Author), Vovk, Tomaž (Author), Kores-Plesničar, Blanka (Author), Grabnar, Iztok (Author)

URLURL - Presentation file, Visit http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131721/ New window

Abstract
Increasing evidence indicates that oxidative damage exists in schizophrenia. Available literature about possible mechanisms of oxidative stress induction was reviewed. Furthermore, possibilities of measuring biomarkers of schizophrenia outside the central nervous system compartment, their specificity for different types of schizophrenia and potential therapeutic strategies to prevent oxidative injuries in schizophrenia were discussed. Datawere extracted from published literature found in Medline, Embase, Biosis,Cochrane and Web of Science, together with hand search of references. Search terms were: schizophrenia, oxidative stress, antipsychotics, antioxidants and fatty acids. Finding a sensitive, specific and non invasive biomarker of schizophrenia, which could be measured in peripheral tissue, still stays an important task. Antioxidant enzymes, markers of lipid peroxidation, oxidatively modified proteins and DNA are most commonly used. Asit considers the supplemental therapy, according to our meta-analysis vitamin E could potentially improve tardive dyskinesia, while for the effect of therapy with polyunsaturated fatty acids there is no clear evidence. Oxidative stress is a part of the pathology in schizophrenia and appears as a promising field to develop new therapeutic strategies. There is a need for well designed, placebo controlled trials with supplementation therapy in schizophrenia.

Language:English
Keywords:shizofrenija, oksidativni stres, maščobne kisline, biokemični markerji
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:FFA - Faculty of Pharmacy
Year:2011
Number of pages:str. 301-312
Numbering:Vol. 9, no. 2
UDC:577
ISSN on article:1570-159X
DOI:10.2174/157015911795596595 Link is opened in a new window
COBISS.SI-ID:2892657 Link is opened in a new window
Views:599
Downloads:160
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Record is a part of a journal

Title:Current neuropharmacology
Publisher:Bentham Science Publishers
ISSN:1570-159X
COBISS.SI-ID:512183065 New window

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