izpis_h1_title_alt

The antioxidant enzyme GPX1 gene polymorphisms are associated with low BMD and increased bone turnover markers
Jurković Mlakar, Simona (Avtor), Osredkar, Joško (Avtor), Preželj, Janez (Avtor), Marc, Janja (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://iospress.metapress.com/content/b021502072781x72/fulltext.pdf Povezava se odpre v novem oknu

Izvleček
Abstract. Recently, oxidative stress has been suggested as participating in the development of osteoporosis. Glutathione peroxidase 1 (GPX1) is one of antioxidant enzymes responsible for the defence of cells against oxidative damage and thus for protection against age related diseases such as osteoporosis. The aim of present study was to associate genetic variances of GPX1 enzyme with bone mineral density (BMD) and biochemical bone turnover markers and to show the influence of antioxidative defence system in genetics of osteoporosis. We evaluated 682 Slovenian subjects: 571 elderly women and 111 elderly men. All subjects were genotyped for the presence of GPX1 gene polymorphisms Pro198Leu and polyAla region. BMD and biochemical markers were also measured. General linear model analysis, adjusted to height, and (one-way) analysis of variance were used to assess differences between the genotype.and haplotype subgroups, respectively. The significant or borderline significant associations were found between the polyAla or the Pro198Leu polymorphisms and total hip BMD (0.018; 0.023, respectively), femoral neck BMD(0.117; 0.026, respectively) and lumbar spine BMD (0.032; 0.086, respectively), and with biochemical bone turnover markers such as plasma osteocalcin (0.027; 0.025, respectively) and serum C-terminal telopeptide of type I collagen concentrations (0.114; 0.012, respectively) in whole group. Haplotype analysis revealed that the 6-T haplotype is associated significantlywith low BMD values (p <0.025) at all measured locations of the skeleton, and with high plasma osteocalcin concentrations (p = 0.008). This study shows for the first time that the polymorphisms polyAla and Pro198Leu ofthe GPX1 gene, individually and in combination, are associated with BMD and therefore may be useful as genetic markers for bone disease. Moreover, it implies the important contribution of the oxidative stress to pathogenesis of osteoporosis.

Jezik:Angleški jezik
Ključne besede:osteoartritis, oksidativni stres, osteokalcin, kostna gostota, BMD meritve
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:str. 71-80
Številčenje:vol. 29, no. 2
UDK:577
ISSN pri članku:0278-0240
DOI:10.3233/DMA-2010-0728 Povezava se odpre v novem oknu
COBISS.SI-ID:2864497 Povezava se odpre v novem oknu
Število ogledov:635
Število prenosov:173
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
:
Objavi na:AddThis
AddThis uporablja piškotke, za katere potrebujemo vaše privoljenje.
Uredi privoljenje...

Gradivo je del revije

Naslov:Disease markers
Skrajšan naslov:Dis. markers
Založnik:Wiley, ASFRA, IOS Press
ISSN:0278-0240
COBISS.SI-ID:1533717 Povezava se odpre v novem oknu

Podobna dela

Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj