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Physical stability of carvedilol in solid dispersions with porous silica
Kovačič, Borut (Avtor), Planinšek, Odon (Avtor), Vrečer, Franc (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.scipharm.at/download.asp?id=807 Novo okno

Izvleček
Adsorption onto silica-based high surface area carriers is a long known methodof improvement drug dissolution rate, which has been described in early 1970s [1]. Porous silica has many silanol groups on its surface and can be used as pharmaceutical excipient, since it is regarded nontoxic after oral application. Due to its porous structure and large specific surface area, porous silica has a great capacity to adsorb organic compounds into its nano-sized pores and can improve physical stability of amorphous drug [2]. Solid dispersions of carvedilol in porous silica (Sylysia 350) were prepared by solvent evaporation in a vacuum evaporator which ensures efficient pore filling procedure [3]. Two sets with different concentrations of carvedilol insolid dispersions were prepared, which differ in pore filling process. Set a) was prepared by one-step filling and set b) by multiple filling of smaller portions of dissolved carvedilol into porous silica. Solid dispersions were characterized by thermal analysis (DSC), X-ray diffraction and nitrogen adsoprtion experiments. Specific surface area and porosity parameters of soliddispersion samples confirm different mechanism of drug loading within silica pores in each experimental set. Results showed that carvedilol is more efficiently ĆpackedĆ inside porous matrix when multiple drug filling procedureof smaller amounts is used as suggested by absence of crystalline state of a drug and greatly reduced porosity, while at the same time physical stability of amorphous carvedilol was most improved. Due to space restriction carvedilol can not crystallize when it is entrapped in a region of pores of smaller diameters than the minimum size of crystalline nucleus. Once the amorphous form of drug is stabilized inside porous silica it remains physically stable against crystallization and water sorption, while pure amorphous drug partially crystallized and adsorbed a detectable amount of moisture.

Jezik:Angleški jezik
Ključne besede:pomožna sredstva, farmacija, trdne disperzije
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.12 - Objavljeni povzetek znanstvenega prispevka na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:Str. 657
UDK:66.02
ISSN pri članku:0036-8709
COBISS.SI-ID:2862449 Povezava se odpre v novem oknu
Število ogledov:578
Število prenosov:79
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del zbornika

Naslov:Abstracts of the 8th Central European Symposium on Pharmaceutical Technology (CESPT), Satellite Symposium: 4th International Graz Congress on Pharmaceutical Engineering, September 16th-18th, Graz, Austria
COBISS.SI-ID:2845297 Novo okno

Gradivo je del revije

Naslov:Scientia Pharmaceutica
Skrajšan naslov:Sci. Pharm.
Založnik:Oesterreichische Apotheker-Verlagsgesellschat MBH
ISSN:0036-8709
COBISS.SI-ID:26371584 Novo okno

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