Influence of caloric value of food on gastric emptying of pellets
Bürmen, Božena (Author), Locatelli, Igor (Author), Mrhar, Aleš (Author), Bogataj, Marija (Author)

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Administration of pellets in fed stomach state can prolong the gastric emptying of pellets in comparison to the administration under fasting conditions [1]. On the basis of literature data we aimed to investigate the influence of caloric value of food on gastric emptying of pellets. A systematic literature search on evaluation of human gastric emptying of pellets based on the technique of gamma scintigraphy was performed in the MEDLINE database. Studies estimating the gastric emptying of pellets under fedconditions were focused. In addition to the caloric value of the meal, a special attention was made on other factors such as, pellets size and density,pellets formulation (filled into capsules or compressed into tablets),a time delay for pellets administration in relation to the time of meal completion, and refreshments provision. The majority of pellets gastric emptying data was presented in terms of pellets t50 values - a time when 50% of the administered pellets emptied the stomach. In order to evaluate the influence of the caloric value of the meal on pellets t50 values a linear regression model was built. In this model the caloric value was regarded as a categorical variable, which was recorded into dummy variables with the lowest caloric value set as a reference. In total 17 studies were recovered, however,only 6 of them met the selection criteria: pellets density between 1.2and 1.5 g/cm3, administration of the pellets at the time of meal completion, pellets filled into capsules, and pellets size in the range from 0.6 to 1.4 mm. In these studies 48 individual values of pellets t50 were collected (6 or 8 subjects per study) and the obtained caloric values were 1200, 1500, 2300, 2800, and 3600 kJ. Mean value of t50 of pellets administered right after the 1200 kJ meal was 136 min. In comparison to the 1200 kJ meal, the mean values of t50 of pellets administered right after 2800 and 3600 kJ meal were significantly longer; 212 min (p=0.031) and 263 min (p=0.003), respectively. No significant difference in terms of mean values of pellets t50 could be noted between the 1200 kJ meal and 1500 or 2300 kJ meal. Our results suggest that gastric emptying of pellets can be more prolonged if administered along with the food with higher caloric value.

Keywords:pelete, praznenje želodca
Work type:Not categorized (r6)
Tipology:1.12 - Published Scientific Conference Contribution Abstract
Organization:FFA - Faculty of Pharmacy
Number of pages:Str. 614
ISSN on article:0036-8709
COBISS.SI-ID:2860913 Link is opened in a new window
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Record is a part of a proceedings

Title:Abstracts of the 8th Central European Symposium on Pharmaceutical Technology (CESPT), Satellite Symposium: 4th International Graz Congress on Pharmaceutical Engineering, September 16th-18th, Graz, Austria
COBISS.SI-ID:2845297 This link opens in a new window

Record is a part of a journal

Title:Scientia Pharmaceutica
Shortened title:Sci. Pharm.
Publisher:Oesterreichische Apotheker-Verlagsgesellschat MBH
COBISS.SI-ID:26371584 This link opens in a new window

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