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Gastro-intestinal lymphatic absorption of Sylibum marianum formulated in self-emulsifying pellets
Voinovich, Dario (Avtor), Serdoz, Francesca (Avtor), Perissutti, Beatrice (Avtor), Hasa, Dritan (Avtor), Pinto, J.F. (Avtor), Zara, G.P. (Avtor), Bargoni, A. (Avtor), Grabnar, Iztok (Avtor)

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Izvleček
The objective of this study was to develop solid self-emulsifying pellets to deliver the poorly bioavailable Milk Thistle extract (Silybum Marianum) [1]. These pellets were prepared via extrusion/spheronization procedure, using a self-emulsifying system or SES (composed of Akoline MCMr, Miglyolr, Tween 80r,Soy Lecithin and Propylene Glycol), microcrystalline cellulose and lactosemonohydrate. To select the most suitable formulations for extrusion and spheronization, an experimental design of experiences was adopted. The screening amongst formulations (13 different blends) was carried out preparing pellets and evaluating extrusion profiles and quality of the spheronized extrudates. The pellets were characterized for sizing and shape, density and hardness. Although more than one type of pellets demonstrated adequate morphological and technological characteristics, pellets having best properties were selected for further biopharmaceutical investigations, including in vitro dissolution, determination of released droplet size and in vivo trials on rats to study serum and lymph levels after oral administration of the pellets. These preliminary technological and pharmacokinetic data demonstrated that extrusion/spheronization is a viable technology to produce self- emulsifying pellets of good quality and able to improve in vivo oral bioavailability of main components of a phytotherapic extract, also enhancing its lymphatic absorption. The authors thank Indena for the kind gift of Sylibum Marianum dry extract.

Jezik:Angleški jezik
Ključne besede:Sylibum Marianum, pelete, biofarmacevtske raziskave
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.12 - Objavljeni povzetek znanstvenega prispevka na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:Str. 616
UDK:615
ISSN pri članku:0036-8709
COBISS.SI-ID:2858609 Povezava se odpre v novem oknu
Število ogledov:498
Število prenosov:131
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del zbornika

Naslov:Abstracts of the 8th Central European Symposium on Pharmaceutical Technology (CESPT), Satellite Symposium: 4th International Graz Congress on Pharmaceutical Engineering, September 16th-18th, Graz, Austria
COBISS.SI-ID:2845297 Povezava se odpre v novem oknu

Gradivo je del revije

Naslov:Scientia Pharmaceutica
Skrajšan naslov:Sci. Pharm.
Založnik:Oesterreichische Apotheker-Verlagsgesellschat MBH
ISSN:0036-8709
COBISS.SI-ID:26371584 Povezava se odpre v novem oknu

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