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Delivering of resveratrol with solid lipid nanoparticles improved mitochondria activity
Teskač, Karmen (Avtor), Pelipenko, Jan (Avtor), Kristl, Julijana (Avtor)

URLURL - Predstavitvena datoteka, za dostop obiščite http://www.scipharm.at/download.asp?id=710 Novo okno

Izvleček
Skin is main target for UV-oxidative stress and their antioxidant defenses can be quickly overcome. The consequences are reflected at the molecular and cellular level. Here, most important organelle included in survival pathway are mitochondria. Recently significant activation of mitochondria-mediated signaling cascades by resveratrol (RSV) has been discovered [1]. RSV is a naturally occurring polyphenolic phytoalexin, which has many beneficial biological effects but on the other hand possess some limitations. Few of these are: poor water solubility, high metabolic rate and frequent dosage -dependent effect in the cellular environment [2]. One of recent progresses that can satisfy all these obstacles of RSV is design of nanosized drug delivery system [3]. The protective effects of RSV in solution or loaded into SLN (SLN-RSV) on radiated keratinocytes were studied comparing with the effects on non-radiated cells. Cosequences of damaged effect of UV-radiation was slightly changed cell morphology, as some fragments of actin fibers appeared and mitochondria activity was weakened and they were dispersed over whole cytoplasm. However, only SLN with incorporated RSV at 100 ìM preserved normal cell morphology and improved mitochondria activity, while the other samples (RSV at 10 or 100 ìM and also SLN-RSV at 10 ìM) showed any significant difference regarding radiated control cells. These effects are ascribed to the transfer of RSV by nanoparticles intracellularly - integrating among mitochondria, where RSV can best realize its Ćanti-stressĆ potential. To conclude, the results clearly revealed the hypothesis that loading of RSV into SLN significantly improve bioavailability and diminish UV-related damage of keratinocytes, and thus providing better photoprotection of cells compared to the application of RSV in solution.

Jezik:Angleški jezik
Ključne besede:koža, UV oksidativni stres
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.12 - Objavljeni povzetek znanstvenega prispevka na konferenci
Organizacija:FFA - Fakulteta za farmacijo
Leto izida:2010
Št. strani:Str. 560
UDK:665.5
ISSN pri članku:0036-8709
COBISS.SI-ID:2846065 Povezava se odpre v novem oknu
Število ogledov:447
Število prenosov:131
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del zbornika

Naslov:Abstracts of the 8th Central European Symposium on Pharmaceutical Technology (CESPT), Satellite Symposium: 4th International Graz Congress on Pharmaceutical Engineering, September 16th-18th, Graz, Austria
COBISS.SI-ID:2845297 Novo okno

Gradivo je del revije

Naslov:Scientia Pharmaceutica
Skrajšan naslov:Sci. Pharm.
Založnik:Oesterreichische Apotheker-Verlagsgesellschat MBH
ISSN:0036-8709
COBISS.SI-ID:26371584 Novo okno

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