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Prognostic impact of nutritional status on overall survival and health-related quality of life in men with advanced prostate cancer
ID Čavka, Luka (Avtor), ID Pohar Perme, Maja (Avtor), ID Rotovnik-Kozjek, Nada (Avtor), ID Šeruga, Boštjan (Avtor)

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Izvleček
Purpose: Prognostic role of nutritional status (NS) in patients with metastatic castrate-resistant prostate cancer (mCRPC) is unknown. We hypothesized that patients’ NS at the presentation of mCRPC is prognostic for health-related quality of life (HRQoL) and overall survival (OS). Methods: We conducted a prospective observational study in mCRPC patients. At enrollment, we allocated each patient into one of four NS categories: (i) well-nourished (WN), (ii) nutritional risk without sarcopenia/cachexia (NR), (iii) sarcopenia, or (iv) cachexia. We sought the prognostic role of the NS for OS and HRQoL by regression models. Results: 141 patients were included into our study. When compared to WN patients, those with NR and cachexia had a higher chance of worse HRQoL (OR 3.45; 95% CI [1.28 to 9.09], and OR 4.17; 95% CI [1.28 to 12.5], respectively), as well as shorter OS (HR 2.04; 95% CI [1.19 to 3.39] and HR 2.9; 95% CI [1.56 to 5.41], respectively). However, when accounting for possible confounding factors, we could not prove the significant importance of NS for chosen outcomes. Conclusions: Suboptimal NS might be an unfavorable prognostic factor for HRQoL and OS. Further interventional studies focusing on therapy or prevention are warranted.

Jezik:Angleški jezik
Ključne besede:metastatic castrate-resistant prostate cancer, nutritional risk, malnutrition, outcomes
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2023
Št. strani:12 str.
Številčenje:Vol. 15, iss. 4, art. 1044
PID:20.500.12556/RUL-155619 Povezava se odpre v novem oknu
UDK:613.2
ISSN pri članku:2072-6643
DOI:10.3390/nu15041044 Povezava se odpre v novem oknu
COBISS.SI-ID:142236931 Povezava se odpre v novem oknu
Datum objave v RUL:08.04.2024
Število ogledov:282
Število prenosov:31
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Nutrients
Skrajšan naslov:Nutrients
Založnik:MDPI
ISSN:2072-6643
COBISS.SI-ID:2948140 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:metastatski na kastracijo odporen rak prostate, prehransko tveganje, podhranjenost

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0321
Naslov:Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrstah raka

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