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NAD+ as the link between oxidative stress, inflammation, caloric restriction, exercise, DNA repair, longevity, and health span
Poljšak, Borut (Avtor), Milisav, Irina (Avtor)

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Izvleček
Oxidative stress and decreased DNA damage repair in vertebrates increase with age also due to lowered cellular NAD+. NAD+ depletion may play a major role in the aging process at the cellular level by limiting (1) energy production, (2) DNA repair, and (3) genomic signaling. In this study, we hypothesize that it is not NAD+ as a cofactor in redox reactions and coenzyme in metabolic processes that has the ultimate role in aging, but rather the role of NAD+ in cellular signaling when used as substrate for sirtuins (SIRT1-7 in mammals) and PARPs [Poly(ADP-ribose) polymerases]. Both sirtuins and PARPs influence many transcription factors and can affect gene expression. As a signaling molecule, NAD+ is consumed in the reaction donating ADP-ribose and releasing nicotinamide (NAM) as a by-product. It seems that aging at the cellular level is associated with a decline of NAD+ and that NAD+ restoration can reverse phenotypes of aging by inducing cellular repair and stress resistance. Adequate intracellular NAD+ concentrations may be an important longevity assurance factor, while lowered cellular NAD+ concentration may negatively influence the life span.

Jezik:Angleški jezik
Ključne besede:ageing, NAD+, oxidative stress, niacin, sirtuins, Poly(ADP-ribose)Polymerases, degenerative disease
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:ZF - Zdravstvena fakulteta
Leto izida:2016
Št. strani:str. 406-413
Številčenje:Vol. 19, no. 5
UDK:612.67/.68
ISSN pri članku:1557-8577
DOI:10.1089/rej.2015.1767 Povezava se odpre v novem oknu
COBISS.SI-ID:5019243 Povezava se odpre v novem oknu
Število ogledov:114
Število prenosov:49
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
 
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Gradivo je del revije

Naslov:Rejuvenation research
Skrajšan naslov:Rejuvenation res.
Založnik:Mary Ann Liebert Inc.
ISSN:1557-8577
COBISS.SI-ID:521921049 Novo okno

Gradivo je financirano iz projekta

Financer:EC - Evropska komisija
Program financ.:H2020 - Horizon 2020 Programme funded by European Commission
Številka projekta:664536
Naslov:Advanced Regional Translation of Excellence into Medical Innovations for Delayed Aging
Akronim:ARTEMIDA
ID projekta:info:eu-repo/grantAgreement/EC/H2020/664536

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