1. Structural isomerism and enhanced lipophilicity of pyrithione ligands of organoruthenium(II) complexes increase inhibition on AChE and BuChEJerneja Kladnik, Samuel Ristovski, Jakob Kljun, Andrea Defant, Ines Mancini, Kristina Sepčić, Iztok Turel, 2020, original scientific article Keywords: Alzheimer’s disease, acetylcholinesterase, butyrylcholinesterase, cholinesterase inhibitor, molecular docking, organoruthenium(II) complexes, pyrithione derivatives
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2. Synthesis, biological evaluation and docking studies of benzoxazoles derived from thymoquinoneUna Glamočlija, Subhash Padhye, Selma Špirtović-Halilović, Amar Osmanović, Elma Veljović, Sunčica Roca, Irena Novaković, Boris Mandić, Iztok Turel, Jakob Kljun, Snežana Trifunović, Emira Kahrović, Sandra Kraljević-Pavelić, Anja Harej, Marko Klobučar, Davorka Završnik, 2018, original scientific article Keywords: thymoquinone, benzoxazoles, anticancer activity, antimicrobial activity, western blotting, molecular docking
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3. Copper(II) and zinc(II) complexes with the clinically used fluconazoleNevena Lj. Stevanović, Ivana Aleksić, Jakob Kljun, Sanja Skaro-Bogojevic, Aleksandar Veselinovic, Jasmina Nikodinović-Runić, Iztok Turel, Miloš I. Djuran, Biljana Đ. Glišić, 2021, original scientific article Keywords: copper(II) complex, zinc(II) complex, fluconazole, antifungal agents, anti-biofilm activity
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4. Structural and functional characterization of an organometallic ruthenium complex as a potential myorelaxant drugTomaž Trobec, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Jakob Kljun, Iztok Turel, Evelyne Benoit, Robert Frangež, 2020, original scientific article Keywords: organoruthenium nitrophenanthroline complex, acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, mouse neuromuscular system, ruthenium, muscle relaxation, physiology, glutathione transferase
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5. Comparison of solution chemical properties and biological activity of ruthenium complexes of selected ß-diketone, 8-hydroxyquinoline and pyrithione ligandsTamás Pivarcsik, Gábor Tóth, Nikoletta Szemerédi, Anita Bogdanov, Gabriella Spengler, Jakob Kljun, Jerneja Kladnik, Iztok Turel, Éva A. Enyedy, 2021, original scientific article Keywords: MTT assay, UV-vis, solution stability, MRSA, albumin binding, ligand effect
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6. Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cellsJerneja Kladnik, James P. C. Coverdale, Jakob Kljun, Hilke Burmeister, Petra Lippman, Francesca G. Ellis, Alan M. Jones, Ingo Ott, Isolda Romero-Canelón, Iztok Turel, 2021, original scientific article Keywords: ruthenium, pyrithione, resistance to chemotherapy, cancer, ovarian, thioredoxin
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7. Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activityTina P. Andrejević, Ivana Aleksić, Marta Počkaj, Jakob Kljun, Dušan Milivojević, Nevena Lj. Stevanović, Jasmina Nikodinović-Runić, Iztok Turel, Miloš I. Djuran, Biljana Đ. Glišić, 2021, original scientific article Keywords: copper(II) complexes, pyridine-4, 5-dicarboxylates, antimicrobial activity, Candida albicans, filamentation, DNA/BSA interaction
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8. Clinically used antifungal azoles as ligands for gold(III) complexesNevena Lj. Stevanović, Jakob Kljun, Ivana Aleksić, Sanja Skaro-Bogojevic, Dušan Milivojević, Aleksandar Veselinovic, Iztok Turel, Miloš I. Djuran, Jasmina Nikodinović-Runić, Biljana Đ. Glišić, 2022, original scientific article Full text (file, 1,32 MB) This document has more files! More... |
9. Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell lineJakob Kljun, Renata Pavlič, Eva Hafner, Tanja Lipec, Sara Moreno-Da Silva, Primož Tič, Iztok Turel, Tomaž Büdefeld, Jure Stojan, Tea Lanišnik-Rižner, 2022, original scientific article Keywords: ruthenium complexes, synthesis, crystal structure, anticancer, aldo-keto reductase, enzyme inhibition
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10. Zinc pyrithione is a potent inhibitor of PL$^{Pro}$ and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replicationJerneja Kladnik, Ana Dolinar, Jakob Kljun, David Perea, Judith Grau-Expósito, Meritxell Genescà, Marko Novinec, Maria J. Buzon, Iztok Turel, 2022, original scientific article Keywords: antiviral agents, SARS-CoV-2, inhibition, pyrithione, zinc
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