21. Structurally optimized potent dual-targeting NBTI antibacterials with an enhanced bifurcated halogen-bonding propensityMaja Kokot, Matjaž Weiss, Irena Zdovc, Martina Hrast, Marko Anderluh, Nikola Minovski, 2021, original scientific article Keywords: NBTIs, DNA gyrase, topoisomerase IV, bifurcated halogen bonds, dual targeting Full text (file, 2,92 MB) This document has more files! More... |
22. The synthesis of (2R)-aziridine-2-carboxylic acid containing dipeptidesSamo Kuzmič, Martina Hrast, Rok Frlan, 2022, original scientific article Keywords: dipeptides, aziridines, biomarkers, warheads, antibacterial agents Full text (file, 406,86 KB) This document has more files! More... |
23. Next-generation heterocyclic electrophiles as small-molecule covalent MurA inhibitorsPéter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György Keserü M., 2022, original scientific article Keywords: covalent inhibitor, heterocyclic electrophiles, cysteine labelling, quaternization, MurA Full text (file, 1,46 MB) This document has more files! More... |
24. Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesisMatic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec, 2023, original scientific article Keywords: fragment-based drug discovery, hit triage, inhibitors, antibacterial agents Full text (file, 1,79 MB) This document has more files! More... |
25. Fragment-sized thiazoles in fragment-based drug discovery campaignsMatic Proj, Martina Hrast, Damijan Knez, Krištof Bozovičar, Katarina Grabrijan, Anže Meden, Stanislav Gobec, Rok Frlan, 2022, original scientific article Keywords: thiazoles, hit profiling, promiscuous compounds, frequent hitters, privileged scaffolds, fragments Full text (file, 2,30 MB) This document has more files! More... |
26. Mur ligase F as a new target for the flavonoids quercitrin, myricetin, and (–)-epicatechinMartina Hrast, Irena Zdovc, Nina Kočevar Glavač, Stanislav Gobec, Rok Frlan, 2023, original scientific article Keywords: MurF, quercitrin, myricetin, (–)-epicatechin, antibacterial activity Full text (file, 1,43 MB) This document has more files! More... |
27. Exploring alternative pathways to target bacterial type II topoisomerases using NBTI antibacterials: beyond halogen-bonding interactionsMaja Kokot, Doroteja Novak, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski, 2023, original scientific article Keywords: DNA gyrase, topoisomerase IV, antibacterial, NBTIs, halogen-bonding interactions, hydrogen-bonding interactions, van der Waals interactions Full text (file, 3,33 MB) This document has more files! More... |
28. Inhibition of MurA enzyme from Escherichia coli by flavonoids and their synthetic analoguesRok Frlan, Martina Hrast, Stanislav Gobec, 2023, original scientific article Keywords: assays, flavonoids, inhibition, inhibitors, peptides, proteins Full text (file, 2,97 MB) This document has more files! More... |
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