11. Psoralen derivatives as inhibitors of mycobacterium tuberculosis proteasomeKaja Rožman, Evan M. Alexander, Eva Ogorevc, Krištof Bozovičar, Izidor Sosič, Courtney C. Aldrich, Stanislav Gobec, 2020, izvirni znanstveni članek Ključne besede: protein degradation, proteasome, Mycobacterium tuberculosis, psoralens, nonpeptidic proteasome inhibitors
Celotno besedilo (datoteka, 6,28 MB) Gradivo ima več datotek! Več... |
12. Novel selective IDO1 inhibitors with isoxazolo[5,4-d]pyrimidin-4(5H)-one scaffoldAna Dolšak, Tomaž Bratkovič, Larisa Mlinarič, Eva Ogorevc, Urban Švajger, Stanislav Gobec, Matej Sova, 2021, izvirni znanstveni članek Ključne besede: indoleamine 2, 3-dioxygenase 1, selective inhibitors, isoxazolo[5, 4-d]pyrimidin-4(5H)-one, immunomodulation, cancer
Celotno besedilo (datoteka, 19,67 MB) Gradivo ima več datotek! Več... |
13. Prioritisation of compounds for 3CL$^{pro}$ inhibitor development on SARS-CoV-2 variantsMarko Jukič, Blaž Škrlj, Gašper Tomšič, Sebastian Pleško, Črtomir Podlipnik, Urban Bren, 2021, izvirni znanstveni članek Ključne besede: COVID-19, SARS-CoV-2, free-energy calculations, in silico drug design, virtual screening, inhibitors, 3C-like protease, M$^{pro}$, 3CL$^{pro}$, high-throughput, chemical library design, machine learning, compound prioritisation
Celotno besedilo (datoteka, 6,56 MB) Gradivo ima več datotek! Več... |
14. 4-phenethyl-1-propargylpiperidine-derived dual inhibitors of butyrylcholinesterase and monoamine oxidase BTjaša Mazej, Damijan Knez, Anže Meden, Stanislav Gobec, Matej Sova, 2021, izvirni znanstveni članek Ključne besede: Alzheimer's disease, butyrylcholinesterase, monoamine oxidase B, inhibitors, multi-target-directed ligands, multifunctional ligands
Celotno besedilo (datoteka, 3,88 MB) Gradivo ima več datotek! Več... |
15. A fine-tuned lipophilicity/hydrophilicity ratio governs antibacterial potency and selectivity of bifurcated halogen bond-forming NBTIsAnja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski, 2021, izvirni znanstveni članek Ključne besede: antibacterials, drug discovery, DNA gyrase inhibitors, topoisomerase IV inhibitors, intercalators, novel bacterial topoisomerase inhibitors, topoisomerase II inhibitors, intercalating agents
Celotno besedilo (datoteka, 6,80 MB) Gradivo ima več datotek! Več... |
16. Molecular dynamics-derived pharmacophore model explaining the nonselective aspect of K$_V$10.1 pore blockersŽan Toplak, Franci Merzel, Luis A. Pardo, Lucija Peterlin-Mašič, Tihomir Tomašič, 2021, izvirni znanstveni članek Ključne besede: cancer, Eag1, hERG, K$_V$10.1 inhibitors, molecular dynamics, pharmacophore
Celotno besedilo (datoteka, 10,02 MB) Gradivo ima več datotek! Več... |
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18. Fragment-sized and bidentate (immuno)proteasome inhibitors derived from cysteine and threonine targeting warheadsLevente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Stanislav Gobec, Izidor Sosič, György Keserü M., 2021, izvirni znanstveni članek Ključne besede: immunoproteasome, benzoxazole-2-carbonitriles, bidentate covalent inhibitors, fragments, non-covalent recognition
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19. Inhibition of MurA enzyme from Escherichia coli and Staphylococcus aureus by diterpenes from Lepechinia meyenii and their synthetic analogsMacarena Funes Chabán, Martina Hrast, Rok Frlan, Dafni G. Graikioti, Constantinos M. Athanassopoulos, María Cecilia Carpinella, 2021, izvirni znanstveni članek Ključne besede: dehydroabietane derivatives, diterpenes, MurA inhibitors, MurF inhibitors, Staphylococcus aureus MurA, Escherichia coli MurA
Celotno besedilo (datoteka, 2,12 MB) Gradivo ima več datotek! Več... |
20. Upregulation of cathepsin X in glioblastomaBernarda Majc, Anamarija Habič, Metka Novak, Ana Rotter, Andrej Porčnik, Jernej Mlakar, Vera Župunski, Urša Pečar Fonović, Damijan Knez, Nace Zidar, Stanislav Gobec, Janko Kos, Tamara Lah Turnšek, Anja Pišlar, Barbara Breznik, 2022, izvirni znanstveni članek Ključne besede: glioblastoma, cathepsin X, γ-enolase, tumor microenvironment, glioblastoma stem cells, cathepsin X inhibitors
Celotno besedilo (datoteka, 3,50 MB) Gradivo ima več datotek! Več... |
