1. Structurally optimized potent dual-targeting NBTI antibacterials with an enhanced bifurcated halogen-bonding propensityMaja Kokot, Matjaž Weiss, Irena Zdovc, Martina Hrast, Marko Anderluh, Nikola Minovski, 2021, original scientific article Keywords: NBTIs, DNA gyrase, topoisomerase IV, bifurcated halogen bonds, dual targeting
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2. Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacyMaja Kokot, Matjaž Weiss, Irena Zdovc, Lidija Šenerović, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast, 2023, original scientific article Keywords: NBTIs, DNA gyrase, topoisomerase IV, antibacterials, MRSA, hERG inhibition, in vivo efficacy
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3. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bondsAnja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh, 2021, original scientific article Keywords: antibacterials, DNA gyrase inhibitors, drug discovery, Staphylococcus aureus, intercalators, novel bacterial topoisomerase inhibitors, NBTIs, symmetrical bifurcated halogen bonds, crystal structure, novel NBTIs mechanism of action, antimicrobials, DNA-binding proteins, drug development, X-ray crystallography
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4. Exploring alternative pathways to target bacterial type II topoisomerases using NBTI antibacterials: beyond halogen-bonding interactionsMaja Kokot, Doroteja Novak, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski, 2023, original scientific article Keywords: DNA gyrase, topoisomerase IV, antibacterial, NBTIs, halogen-bonding interactions, hydrogen-bonding interactions, van der Waals interactions
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5. Structural aspects of Mycobacterium tuberculosis DNA gyrase targeted by novel bacterial topoisomerase inhibitorsMaja Kokot, Martina Hrast, Lipeng Feng, Lesley A Mitchenall, David M. Lawson, Anthony Maxwell, Tanya Parish, Nikola Minovski, Marko Anderluh, 2024, original scientific article Keywords: NBTIs, DNA gyrase, M. tuberculosis, crystal structure, bifurcated halogen bonds
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6. Enhancing antibacterial efficacyMaša Zorman, Maja Kokot, Irena Zdovc, Lidija Šenerović, Mina Mandic, Nace Zidar, Andrej Emanuel Cotman, Martina Durcik, Lucija Peterlin-Mašič, Nikola Minovski, Marko Anderluh, Martina Hrast, 2024, original scientific article Keywords: topoisomerase inhibitors, NBTIs, efflux pump inhibitors, ESKAPE pathogens, antimicrobial resistance, bacterial biofilms
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