1. Synthesis of conformationally constrained D-Glu-meso-DAP analogs as innate immune agonistsSamo Guzelj, Žiga Jakopin, 2020, original scientific article Keywords: NOD1 agonist, constrained meso-DAP mimetics, NOD1 activation, innate immune agonist, bioisosteric replacement, rigidization
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2. Načrtovanje in sinteza zaviralcev ksantinske oksidaze s piridil-1,2,4-oksadiazolnim ogrodjemSamo Guzelj, 2017, master's thesis Keywords: zavrialci ksantinske oksidaze, 1, 2, 4-oksadiazol, zamenjava skeleta, Alopurinol, sinteza spojin, putika
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3. Novel scaffolds for modulation of NOD2 identified by pharmacophore-based virtual screeningSamo Guzelj, Tihomir Tomašič, Žiga Jakopin, 2022, original scientific article Keywords: antagonist, homology modeling, NOD2, Nucleotide-binding oligomerization, pharmacophore modeling, virtual screening
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4. Nucleotide-binding oligomerization domain 1/Toll-like receptor 4 co-engagement promotes non-specific immune response against K562 cancer cellsSamo Guzelj, Žiga Jakopin, 2022, original scientific article Keywords: NOD1 agonist, TLR4 agonist, LPS, synergy, cytolytic activity, PBMC, NK cells, K562
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5. Discovery of desmuramylpeptide NOD2 agonists with single-digit nanomolar potencySamo Guzelj, Špela Janež, Žiga Jakopin, 2022, original scientific article Keywords: NOD2, desmuramylpeptide, immunostimulant, adamantane, PBMC cytotoxicity, K562, agonists, cells, peptides and proteins, reaction products, toxicological synergy
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6. Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activitySamo Guzelj, Sanja Nabergoj, Martina Gobec, Stane Pajk, Veronika Weiss, Bram Slütter, Ruža Frkanec, Adela Štimac, Primož Šket, Janez Plavec, Irena Mlinarič-Raščan, Žiga Jakopin, 2021, original scientific article Keywords: reaction products, peptides, proteins, cells, organic compounds, toxicity
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7. Structure-guided design of D-galactal derivatives with high affinity and selectivity for the galectin-8 n-terminal domainMujtaba Hassan, Floriane Baussière, Samo Guzelj, Anders Sundin, Maria Håkansson, Rebeka Kovačič, Hakon Leffler, Tihomir Tomašič, Marko Anderluh, Žiga Jakopin, 2021, original scientific article Keywords: Galectin-8N, d-galactal, benzimidazole, selectivity, X-ray crystallography, cytokine secretion
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9. Covalently conjugated NOD2/TLR7 agonists are potent and versatile immune potentiatorsSamo Guzelj, Matjaž Weiss, Bram Slütter, Ruža Frkanec, Žiga Jakopin, 2022, original scientific article Keywords: immunostimulatory activity, vaccines, immune responses, pattern recognition receptors, synthesis of NOD2 agonist, Toll-like receptor 7
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10. Lipidation of NOD2 agonists with adamantane and stearoyl moieties differentially regulates their In vivo adjuvant activitySamo Guzelj, Marcela Šišić, Špela Janež, Leo Frkanec, Ruža Frkanec, Žiga Jakopin, 2022, original scientific article Keywords: NOD2 agonist, vaccine adjuvant, adamantane, immunopotentiators, desmuramylpeptides
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