1. Synthesis of 3-amino-4-substituted monocyclic ß-lactams—important structural motifs in medicinal chemistryKatarina Grabrijan, Nika Strašek Benedik, Stanislav Gobec, 2022, original scientific article Keywords: monocyclic ß-lactam, Staudinger [2+2] cyclocondensation, cerium ammonium nitrate, hydrazine hydrate, 3-amino-4-substituted azetidin-2-one, inhibitory activities
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2. Simulation- and AI-directed optimization of 4,6-substituted 1,3,5-triazin-2(1H)-ones as inhibitors of human DNA topoisomerase IIαBarbara Herlah, Tjaša Goričan, Nika Strašek Benedik, Simona Golič Grdadolnik, Izidor Sosič, Andrej Perdih, 2024, original scientific article Keywords: molecular design, molecular simulations, deep learning, human DNA, topoisomerase IIα, catalytic inhibitors, anticancer agents
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3. Tunable heteroaromatic nitriles for selective bioorthogonal click reaction with cysteineMatic Proj, Nika Strašek Benedik, Stane Pajk, Damijan Knez, Izidor Sosič, 2023, original scientific article Keywords: labeling, monomers, nitrogen compounds, peptides, reactivity, proteins
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4. Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodiesMatic Proj, Mitja Zidar, Blaž Lebar, Nika Strašek Benedik, Goran Miličić, Aleš Žula, Stanislav Gobec, 2022, original scientific article Keywords: viscosity, protein formulations, biopharmaceuticals, viscosity-reducing agents, computational screening
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5. Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s)Katarina Grabrijan, Nika Strašek Benedik, Alen Krajnc, Krištof Bozovičar, Damijan Knez, Matic Proj, Irena Zdovc, Izidor Sosič, Martina Hrast, Stanislav Gobec, 2024, original scientific article Keywords: antibacterial agents, monocyclic-β-lactams, penicillin-binding proteins, covalent inhibitors, transpeptidase
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6. Targeting TAK1Nika Strašek Benedik, Matic Proj, Christian Steinebach, Matej Sova, Izidor Sosič, 2025, review article Keywords: transforming growth factor-β-activated kinase 1, inhibitors, inflammation, tumor necrosis factor, signaling pathways, structure-activity relationship
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