1. Določanje mehanizmov agregacije monoklonskih protiteles v bioloških zdravilihMitja Zidar, 2016, master's thesis Keywords: biofizika, proteini, monoklonska protitelesa, agregacija, koloidna stabilnost, konformacijska stabilnost, diferencialna kalorimetrija, gelska izključitvena kromatografija, dinamično sipanje svetlobe Full text (file, 3,47 MB) |
2. Fizikalna optimizacija procesov čiščenja bioloških zdravilMaša Lah, 2022, master's thesis Keywords: fizikalna optimizacija, agregacija, gelska izključitvena kromatografija, intrinzična proteinska fluorescenca, koloidna stabilnost, konformacijska stabilnost, monoklonska protitelesa, proteini Full text (file, 3,45 MB) |
3. Analysis and prediction of aggregation and degradation in protein-based biopharmaceuticalsMitja Zidar, 2020, doctoral dissertation Keywords: soft matter physics, monoclonal antibody, aggregation, degradation, viscosity, biopharmaceuticals, proteins Full text (file, 8,16 MB) |
4. Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodiesMatic Proj, Mitja Zidar, Blaž Lebar, Nika Strašek Benedik, Goran Miličić, Aleš Žula, Stanislav Gobec, 2022, original scientific article Keywords: viscosity, protein formulations, biopharmaceuticals, viscosity-reducing agents, computational screening Full text (file, 2,19 MB) This document has more files! More... |
5. Polysorbate stabilityBlaž Lebar, Tinkara Lekić, Pija Košir, Miha Kastelic, Mitja Zidar, Janez Mravljak, Stane Pajk, 2024, original scientific article Keywords: polysorbates, primary packaging material, hydrolysis, stability, histidine, acetic acid, principal component analysis Full text (file, 2,69 MB) This document has more files! More... |
6. Alternative buffer systems in biopharmaceutical formulations and their effect on protein stabilityBlaž Lebar, Mitja Zidar, Janez Mravljak, Roman Šink, Aleš Žula, Stane Pajk, 2024, original scientific article Keywords: biopharmaceuticals, buffer, stress, aggregates, alternative buffers, stability Full text (file, 2,17 MB) This document has more files! More... |
7. Small scale model for predicting transportation-induced particle formation in biotherapeuticsUrška Pečarič Strnad, Petra Zalokar, Natan Osterman, Mitja Zidar, 2025, original scientific article Keywords: biophysics, proteins, aggregation, adsorption, biopharmaceuticals, viscoelastic films, air-liquid interface Full text (file, 2,45 MB) This document has more files! More... |
8. A multifaceted approach to understanding protein-buffer interactions in biopharmaceuticalsBlaž Lebar, Maria Orehova, Boštjan Japelj, Ernest Šprager, Rok Podlipec, Tilen Knaflič, Iztok Urbančič, Benjamin Knez, Mitja Zidar, Jure Cerar, Janez Mravljak, Aleš Žula, Denis Arčon, Janez Plavec, Stane Pajk, 2025, original scientific article Keywords: buffer, interaction, methyl fingerprinting, molecular dynamics, monoclonal antibody, nuclear magnetic resonance Full text (file, 4,94 MB) This document has more files! More... |