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2. Strukturno podprto načrtovanje in optimizacija novih zaviralcev bakterijskih topoizomeraz tipa II z zmanjšanim kardiotoksičnim potencialomMaja Kokot, 2024, doctoral dissertation Keywords: Bakterijske topoizomeraze tipa II, DNA giraza, topoizomeraza IV, NBTI, protibakterijsko delovanje, hERG, multidimenzionalni QSAR, in vivo učinkovitost, razcepljene haloge vezi Full text (file, 24,61 MB) |
3. A fine-tuned lipophilicity/hydrophilicity ratio governs antibacterial potency and selectivity of bifurcated halogen bond-forming NBTIsAnja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski, 2021, original scientific article Keywords: antibacterials, drug discovery, DNA gyrase inhibitors, topoisomerase IV inhibitors, intercalators, novel bacterial topoisomerase inhibitors, topoisomerase II inhibitors, intercalating agents Full text (file, 6,80 MB) This document has more files! More... |
4. The structural features of novel bacterial topoisomerase inhibitors that define their activity on topoisomerase IVMaja Kokot, Marko Anderluh, Martina Hrast, Nikola Minovski, 2022, review article Keywords: genetics, inhibition, bacteria, phenyls Full text (file, 5,07 MB) This document has more files! More... |
5. Structurally optimized potent dual-targeting NBTI antibacterials with an enhanced bifurcated halogen-bonding propensityMaja Kokot, Matjaž Weiss, Irena Zdovc, Martina Hrast, Marko Anderluh, Nikola Minovski, 2021, original scientific article Keywords: NBTIs, DNA gyrase, topoisomerase IV, bifurcated halogen bonds, dual targeting Full text (file, 2,92 MB) This document has more files! More... |
6. Exploring alternative pathways to target bacterial type II topoisomerases using NBTI antibacterials: beyond halogen-bonding interactionsMaja Kokot, Doroteja Novak, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski, 2023, original scientific article Keywords: DNA gyrase, topoisomerase IV, antibacterial, NBTIs, halogen-bonding interactions, hydrogen-bonding interactions, van der Waals interactions Full text (file, 3,33 MB) This document has more files! More... |
7. Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacyMaja Kokot, Matjaž Weiss, Irena Zdovc, Lidija Senerovic, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast, 2023, original scientific article Keywords: NBTIs, DNA gyrase, topoisomerase IV, antibacterials, MRSA, hERG inhibition, in vivo efficacy Full text (file, 3,61 MB) This document has more files! More... |