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1. Spremljanje razpada polisorbatov 20 in 80 v različnih placebo formulacijah s tekočinsko kromatografijo ter jedrsko magnetno resonanco
Pija Košir, 2022, master's thesis/paper

Keywords: polisorbat 20, polisorbat 80, razgradnja, tekočinska kromatografija visoke ločljivosti, jedrska magnetna resonanca
Full text (file, 2,51 MB)

2. Karakterizacija interakcije katepsina B s heparinom z mestno-specifično mutagenezo
Blaž Lebar, 2020, master's thesis

Keywords: katepsin B, heparin, alosterična regulacija, inhibitor
Full text (file, 1,91 MB)

3. Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies
Matic Proj, Mitja Zidar, Blaž Lebar, Nika Strašek Benedik, Goran Miličić, Aleš Žula, Stanislav Gobec, 2022, original scientific article

Keywords: viscosity, protein formulations, biopharmaceuticals, viscosity-reducing agents, computational screening
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4. The search for novel proline analogs for viscosity reduction and stabilization of highly concentrated monoclonal antibody solutions
Monika Prašnikar, Matic Proj, Maja Bjelošević Žiberna, Blaž Lebar, Benjamin Knez, Nika Kržišnik, Robert Roškar, Stanislav Gobec, Iztok Grabnar, Aleš Žula, Pegi Ahlin Grabnar, 2024, original scientific article

Keywords: proline analogs, monoclonal antibodies, subcutaneous administration, viscosity reducers, high concentration
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5. Polysorbate stability
Blaž Lebar, Tinkara Lekić, Pija Košir, Miha Kastelic, Mitja Zidar, Janez Mravljak, Stane Pajk, 2024, original scientific article

Keywords: polysorbates, primary packaging material, hydrolysis, stability, histidine, acetic acid, principal component analysis
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6. Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability
Blaž Lebar, Mitja Zidar, Janez Mravljak, Roman Šink, Aleš Žula, Stane Pajk, 2024, original scientific article

Keywords: biopharmaceuticals, buffer, stress, aggregates, alternative buffers, stability
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7. A multifaceted approach to understanding protein-buffer interactions in biopharmaceuticals
Blaž Lebar, Maria Orehova, Boštjan Japelj, Ernest Šprager, Rok Podlipec, Tilen Knaflič, Iztok Urbančič, Benjamin Knez, Mitja Zidar, Jure Cerar, Janez Mravljak, Aleš Žula, Denis Arčon, Janez Plavec, Stane Pajk, 2025, original scientific article

Keywords: buffer, interaction, methyl fingerprinting, molecular dynamics, monoclonal antibody, nuclear magnetic resonance
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