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1. Discovery of desmuramylpeptide NOD2 agonists with single-digit nanomolar potency
Samo Guzelj, Špela Janež, Žiga Jakopin, 2022, original scientific article

Keywords: NOD2, desmuramylpeptide, immunostimulant, adamantane, PBMC cytotoxicity, K562, agonists, cells, peptides and proteins, reaction products, toxicological synergy
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2. Lipidation of NOD2 agonists with adamantane and stearoyl moieties differentially regulates their In vivo adjuvant activity
Samo Guzelj, Marcela Šišić, Špela Janež, Leo Frkanec, Ruža Frkanec, Žiga Jakopin, 2022, original scientific article

Keywords: NOD2 agonist, vaccine adjuvant, adamantane, immunopotentiators, desmuramylpeptides
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3. Distinctive immune signatures driven by structural alterations in desmuramylpeptide NOD2 agonists
Špela Janež, Samo Guzelj, Petra Kocbek, Eveline A. de Vlieger, Bram Slütter, Žiga Jakopin, 2024, original scientific article

Keywords: agonists, cells, peptides, proteins, reaction products, toxicity
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4. Linker chemistry and connectivity fine-tune the immune response and kinetic solubility of conjugated NOD2/TLR7 agonists
Špela Janež, Samo Guzelj, Žiga Jakopin, 2024, original scientific article

Keywords: agonists, amines, conjugate acid-base pairs, peptides, proteins, solubility
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5. Proučevanje vpliva zamenjave glicina z aromatskimi in heteroaromatskimi aminokislinami na agonistično aktivnost dezmuramilpeptidov na nukleotid-vezočo oligomerizacijsko domeno vsebujoč protein 2
Klemen Bele, 2024, master's thesis/paper

Keywords: Receptor NOD2, agonisti NOD2, dezmuramilpeptidi, odnos med strukturo in delovanjem, imunski sistem
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